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Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study - PubMed

  • ️Sun Jan 01 2023

Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study

Yi-Ting Ko et al. BMC Ophthalmol. 2023.

Abstract

Background: Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (DED), and corneal surface damage.

Methods: In a matched nationwide cohort study, we evaluated the risk of DED and corneal surface damage associated with IBD. Multivariable Cox proportional hazards regression analyses were implemented to estimate the risk of ocular complications.

Results: A total of 54,293 matched pairs were included for analyses. The median follow-up time was 8.3 years (interquartile range: 5.5 - 10.5). The period incidence of DED was 8.18 and 5.42 per 1000 person-years in the IBD and non-IBD groups, respectively. After adjusting for confounders, statistically significant associations were found between IBD and DED [adjusted hazard ratio (aHR): 1.43, 95% confidence interval (CI): 1.35 - 1.51, p < 0.0001], Sjögren's syndrome-related (aHR: 1.67, 95% CI:1.46 - 1.90, p < 0.0001) and non-Sjögren's syndrome-related subtypes (aHR: 1.38, 95% CI: 1.30 - 1.46, p < 0.0001). Furthermore, increased risks of corneal surface damage (aHR: 1.13, 95% CI: 1.03 - 1.24, p = 0.0094) among the patients with IBD were observed when compared with the controls. Other independent factors associated with corneal surface damage were age (aHR: 1.003), sex (male vs. female, aHR: 0.85), and monthly insurance premium (501-800 vs. 0-500 U.S. dollars, aHR: 1.45; ≥ 801 vs. 0-500 U.S. dollars, aHR: 1.32).

Conclusions: Our results suggested that IBD was an independent risk factor for DED and ocular surface damage. Clinical strategies are needed to prevent visual impairment or losses in these susceptible patients.

Keywords: Crohn's disease; Keratoconjunctivitis sicca; Peripheral ulcerative keratitis; Ulcerative colitis.

© 2023. BioMed Central Ltd., part of Springer Nature.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1

Cumulative risk of dry eye disease (DED) (A), Sjögren's syndrome (SS)-related DED (B), non-SS-related DED (C), and corneal surface damage (D) between patients with and without inflammatory bowel disease with number of subjects at risk

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References

    1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:75–92. https://www.sciencedirect.com/science/article/abs/pii/S1542012412700812?.... - PubMed
    1. Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017;15:334–365. doi: 10.1016/j.jtos.2017.05.003. - DOI - PubMed
    1. Kuo YK, Lin IC, Chien LN, Lin TY, How YT, Chen KH, et al. Dry eye disease: A review of epidemiology in Taiwan, and its clinical treatment and merits. J Clin Med. 2019;8:1227. doi: 10.3390/jcm8081227. - DOI - PMC - PubMed
    1. Lin PY, Tsai SY, Cheng CY, Liu JH, Chou P, Hsu WM. Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study. Ophthalmology. 2003;110:1096–1101. doi: 10.1016/S0161-6420(03)00262-8. - DOI - PubMed
    1. Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017;15:276–283. doi: 10.1016/j.jtos.2017.05.008. - DOI - PubMed

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