Strategic and Innovative Roles of lncRNAs Regulated by Naturally-derived Small Molecules in Cancer Therapy - PubMed

Review

Strategic and Innovative Roles of lncRNAs Regulated by Naturally-derived Small Molecules in Cancer Therapy

Ayşe Hale Alkan et al. Curr Med Chem. 2024.

Abstract

In the field of precision and personalized medicine, the next generation sequencing method has begun to take an active place as genome-wide screening applications in the diagnosis and treatment of diseases. Studies based on the determination of the therapeutic efficacy of personalized drug use in cancer treatment in the size of the transcriptome and its extension, lncRNA, have been increasing rapidly in recent years. Targeting and/or regulating noncoding RNAs (ncRNAs) consisting of long noncoding RNAs (lncRNAs) are promising strategies for cancer treatment. Within the scope of rapidly increasing studies in recent years, it has been shown that many natural agents obtained from biological organisms can potentially alter the expression of many lncRNAs associated with oncogenic functions. Natural agents include effective small molecules that provide anti-cancer effects and have been used as chemotherapy drugs or in combination with standard anti-cancer drugs used in routine treatment. In this review, it was aimed to provide detailed information about the potential of natural agents to regulate and/or target non-coding RNAs and their mechanisms of action to provide an approach for cancer therapy. The discovery of novel anti-cancer targets and subsequent development of effective drugs or combination strategies that are still needed for most cancers will be promising for cancer treatment.

Keywords: Cancer; anti-oxidant.; lncRNA; natural agents; personalized medicine; small molecules.

Similar articles

• LncRNAs in tumor microenvironment: The potential target for cancer treatment with natural compounds and chemical drugs.

  Liu QP, Lin JY, An P, Chen YY, Luan X, Zhang H. Liu QP, et al. Biochem Pharmacol. 2021 Nov;193:114802. doi: 10.1016/j.bcp.2021.114802. Epub 2021 Oct 19. Biochem Pharmacol. 2021. PMID: 34678226 Review.

• Long noncoding RNAs in cancer: From discovery to therapeutic targets.

  Choudhari R, Sedano MJ, Harrison AL, Subramani R, Lin KY, Ramos EI, Lakshmanaswamy R, Gadad SS. Choudhari R, et al. Adv Clin Chem. 2020;95:105-147. doi: 10.1016/bs.acc.2019.08.003. Epub 2019 Oct 31. Adv Clin Chem. 2020. PMID: 32122521 Review.

• Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy.

  Zhao R, Fu J, Zhu L, Chen Y, Liu B. Zhao R, et al. J Hematol Oncol. 2022 Feb 5;15(1):14. doi: 10.1186/s13045-022-01230-6. J Hematol Oncol. 2022. PMID: 35123522 Free PMC article. Review.

• Targeting long non-coding RNAs in cancers: progress and prospects.

  Li CH, Chen Y. Li CH, et al. Int J Biochem Cell Biol. 2013 Aug;45(8):1895-910. doi: 10.1016/j.biocel.2013.05.030. Epub 2013 Jun 4. Int J Biochem Cell Biol. 2013. PMID: 23748105 Review.

• Targeting long non coding RNA by natural products: Implications for cancer therapy.

  Homayoonfal M, Asemi Z, Yousefi B. Homayoonfal M, et al. Crit Rev Food Sci Nutr. 2023;63(20):4389-4417. doi: 10.1080/10408398.2021.2001785. Epub 2021 Nov 16. Crit Rev Food Sci Nutr. 2023. PMID: 34783279 Review.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Bentham Science Publishers Ltd.