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Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder - PubMed

Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder

Jhin Goo Chang et al. Psychiatry Investig. 2023 Nov.

Abstract

Objective: This review aims to investigate the progression of neuroablation, along with documented clinical efficacy and safety, in the management of treatment-resistant obsessive-compulsive disorder (OCD).

Methods: We searched and compiled clinical research results of neuroablation therapy reported to date. We extracted outcomes related to clinical efficacy, side effects, and surgical complications. Additionally, we summarized key claims and findings.

Results: Neuroablative intervention is a potential treatment approach for refractory OCD. Recent advancements, such as real-time magnetic resonance monitoring and minimally invasive techniques employing ultrasound and laser, offer distinct advantages in terms of safety and comparative efficacy when compared to conventional methods. However, the absence of randomized controlled trials and long-term outcome data underscores the need for cautious consideration when selecting neuroablation.

Conclusion: Neuroablative intervention shows promise for refractory OCD, but vigilant consideration is essential in both patient selection and surgical method choices due to the potential for rare yet serious complications.

Keywords: Ablation techniques; Magnetic resonance imaging, interventional; Obsessive-compulsive disorder; Psychosurgery; Refractory.

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Conflict of interest statement

Conflicts of Interest

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.

Surgical procedure of MR-guided focused ultrasound capsulotomy. Adapted from Convergence Research Policy Center; 2019. [37], with permission of the Convergence Research Policy Center 2019. MR, magnetic resonance.

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References

    1. Grant JE. Obsessive-compulsive disorder. N Engl J Med. 2014;371:646–653. - PubMed
    1. Reddy YCJ, Sundar AS, Narayanaswamy JC, Math SB. Clinical practice guidelines for obsessive-compulsive disorder. Indian J Psychiatry. 2017;59(Suppl 1):S74–S90. - PMC - PubMed
    1. Robbins TW, Vaghi MM, Banca P. Obsessive-compulsive disorder: puzzles and prospects. Neuron. 2019;102:27–47. - PubMed
    1. Greenberg BD, Rauch SL, Haber SN. Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology. 2010;35:317–336. - PMC - PubMed
    1. Patel SR, Aronson JP, Sheth SA, Eskandar EN. Lesion procedures in psychiatric neurosurgery. 2013;80:S31.e9–S31.e16. - PubMed

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