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Evolution of neurosurgical advances and nuances in medulloblastoma therapy - PubMed

Review

. 2024 Apr;40(4):1031-1044.

doi: 10.1007/s00381-023-06239-x. Epub 2023 Dec 19.

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Review

Evolution of neurosurgical advances and nuances in medulloblastoma therapy

Julian S Rechberger et al. Childs Nerv Syst. 2024 Apr.

Abstract

Medulloblastoma, the most common malignant brain tumor in children, presents a complex treatment challenge due to its propensity for infiltrative growth within the posterior fossa and its potential attachment to critical anatomical structures. Central to the management of medulloblastoma is the surgical resection of the tumor, which is a key determinant of patient prognosis. However, the extent of surgical resection (EOR), ranging from gross total resection (GTR) to subtotal resection (STR) or even biopsy, has been the subject of extensive debate and investigation within the medical community. Today, the impact of neurosurgical EOR on the prognosis of medulloblastoma patients remains a complex and evolving area of investigation. The conflicting findings in the literature, the challenges posed by critical surrounding anatomical structures, the potential for surgical complications and neurologic morbidity, and the nuanced interactions with molecular subgroups all contribute to the complexity of this issue. As the field continues to advance, the imperative to strike a delicate balance between maximizing resection and preserving quality of life remains central to the management of medulloblastoma patients.

Keywords: Extent of resection; Historical; Intraoperative MRI; Medulloblastoma; Molecular subgroups; Neurosurgery; Second-look surgery.

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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References

    1. Ostrom QT, Price M, Ryan K, Edelson J, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS (2022) CBTRUS statistical report: pediatric brain tumor foundation childhood and adolescent primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol 24:iii1–iii38. https://doi.org/10.1093/neuonc/noac161
    1. Smoll NR, Drummond KJ (2012) The incidence of medulloblastomas and primitive neurectodermal tumours in adults and children. J Clin Neurosci 19:1541–1544. https://doi.org/10.1016/j.jocn.2012.04.009 - DOI - PubMed
    1. Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS (2015) Alex’s Lemonade Stand Foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol 16(Suppl 10):x1–x36. https://doi.org/10.1093/neuonc/nou327 - DOI - PubMed
    1. Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS (2021) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol 23:iii1–iii105. https://doi.org/10.1093/neuonc/noab200
    1. Muskens IS, Feng Q, Francis SS, Walsh KM, McKean-Cowdin R, Gauderman WJ, de Smith AJ, Wiemels JL (2020) Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv 2:vdaa089. https://doi.org/10.1093/noajnl/vdaa089

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