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Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review - PubMed

️Mon Jan 01 2024

Review

Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review

Anastasia Tsambika Zanettoullis et al. Int J Mol Sci. 2024.

Abstract

The aim of this systematic review was to examine if chronic or acute stress, measured by questionnaires or physiological biomarkers, has a separate impact on each different stage in the IVF process. A systematic search of peer-reviewed literature was performed in three databases with keywords. Preselection included 46 articles, and in all, 36 articles were included. Most studies concluded that stress has a negative effect on IVF treatment. The egg retrieval time point was most affected by chronic and acute stress. Through this research, there may be an association between chronic stress and the fertilization stage. Only chronic stress impacted the embryo transfer stage and further evidence suggested that stress decreased during this stage. The pregnancy rate stage was weakly associated with stress. Follicular cortisol was found to affect three stages. Chronic and acute stress significantly and negatively affected the egg retrieval time point. Chronic stress was associated with a lesser extent with the fertilization point, and no significant relationship between acute stress and the embryo transfer and pregnancy rate stages were found. Follicular cortisol was found to affect the process. This review contributes to the research of the relationship between stress and IVF success.

Keywords: IVF; acute stress; chronic stress; systematic review.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Prisma Flowchart. * Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers). ** If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools. From: Page et al., 2021 [22].

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References

1. World Health Organization (WHO) Infertility. 2023. [(accessed on 6 July 2023)]. Available online: https://www.who.int/health-topics/infertility#tab=tab_1.
1. Leslie S.W., Soon-Sutton T.L., Khan M.A.B. Stat Pearls. Stat Pearls Publishing; Treasure Island, FL, USA: 2022. [(accessed on 6 July 2023)]. Male Infertility. Updated 28 November 2022. Available online: https://www.ncbi.nlm.nih.gov/books/NBK562258.
1. Walker M.H., Tobler K.J. Stat Pearls. Stat Pearls Publishing; Treasure Island, FL, USA: 2022. [(accessed on 6 July 2023)]. Female Infertility. Updated 26 May 2022. Available online: https://www.ncbi.nlm.nih.gov/books/NBK556033.
1. Deatsman S., Vasilopoulos T., Rhoton-Vlasak A. Age and fertility: A study on patient awareness. JBRA Assist. Reprod. 2016;20:99–106. doi: 10.5935/1518-0557.20160024. - DOI - PMC - PubMed
1. ESHRE ART Fact Sheet (June 2014) European Society of Human Reproduction and Embryology, June 2014. [(accessed on 6 July 2023)]. Available online: https://www.eshre.eu/~/media/sitecore-files/Annual-meeting/Munich/ARTfac....

Effect of Stress on Each of the Stages of the IVF Procedure: A Systematic Review - PubMed