Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase - PubMed

Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase

T A Peterson et al. Mol Cell Biol. 1985 Jan.

Abstract

We have cloned CDC9, the structural gene for Saccharomyces cerevisiae DNA ligase, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of DNA ligase mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the CDC7 and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in DNA ligase mRNA levels.

Similar articles

• Induction of yeast DNA ligase genes in exponential and stationary phase cultures in response to DNA damaging agents.

  Johnson AL, Barker DG, Johnston LH. Johnson AL, et al. Curr Genet. 1986;11(2):107-12. doi: 10.1007/BF00378201. Curr Genet. 1986. PMID: 3329047

• The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.

  Johnston LH. Johnston LH. Mol Gen Genet. 1979 Feb 16;170(1):89-92. doi: 10.1007/BF00268583. Mol Gen Genet. 1979. PMID: 375019

• The nucleotide sequence of the DNA ligase gene (CDC9) from Saccharomyces cerevisiae: a gene which is cell-cycle regulated and induced in response to DNA damage.

  Barker DG, White JH, Johnston LH. Barker DG, et al. Nucleic Acids Res. 1985 Dec 9;13(23):8323-37. doi: 10.1093/nar/13.23.8323. Nucleic Acids Res. 1985. PMID: 3909103 Free PMC article.

• Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase.

  Johnston LH, Nasmyth KA. Johnston LH, et al. Nature. 1978 Aug 31;274(5674):891-3. doi: 10.1038/274891a0. Nature. 1978. PMID: 355897 No abstract available.

• DNA-damage inducible genes.

  Papathanasiou MA, Fornace AJ Jr. Papathanasiou MA, et al. Cancer Treat Res. 1991;57:13-36. doi: 10.1007/978-1-4615-3872-1_2. Cancer Treat Res. 1991. PMID: 1686714 Review. No abstract available.

Cited by

• Transcriptional regulation of the cell cycle-dependent thymidylate synthase gene of Saccharomyces cerevisiae.

  McIntosh EM, Ord RW, Storms RK. McIntosh EM, et al. Mol Cell Biol. 1988 Nov;8(11):4616-24. doi: 10.1128/mcb.8.11.4616-4624.1988. Mol Cell Biol. 1988. PMID: 3062362 Free PMC article.

• Yeast chromosome replication and segregation.

  Newlon CS. Newlon CS. Microbiol Rev. 1988 Dec;52(4):568-601. doi: 10.1128/mr.52.4.568-601.1988. Microbiol Rev. 1988. PMID: 3070325 Free PMC article. Review. No abstract available.

• Mitochondrial DNA ligase function in Saccharomyces cerevisiae.

  Donahue SL, Corner BE, Bordone L, Campbell C. Donahue SL, et al. Nucleic Acids Res. 2001 Apr 1;29(7):1582-9. doi: 10.1093/nar/29.7.1582. Nucleic Acids Res. 2001. PMID: 11266561 Free PMC article.

• Induction of yeast DNA ligase genes in exponential and stationary phase cultures in response to DNA damaging agents.

  Johnson AL, Barker DG, Johnston LH. Johnson AL, et al. Curr Genet. 1986;11(2):107-12. doi: 10.1007/BF00378201. Curr Genet. 1986. PMID: 3329047

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Molecular Biology Databases

  • Saccharomyces Genome Database