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Novel Therapeutic Strategies in Alzheimer's Disease: Pitfalls and Challenges of Anti-Amyloid Therapies and Beyond - PubMed

  • ️Mon Jan 01 2024

Review

Novel Therapeutic Strategies in Alzheimer's Disease: Pitfalls and Challenges of Anti-Amyloid Therapies and Beyond

Giacomo Tondo et al. J Clin Med. 2024.

Abstract

Alzheimer's disease (AD) causes a significant challenge to global healthcare systems, with limited effective treatments available. This review examines the landscape of novel therapeutic strategies for AD, focusing on the shortcomings of traditional therapies against amyloid-beta (Aβ) and exploring emerging alternatives. Despite decades of research emphasizing the role of Aβ accumulation in AD pathogenesis, clinical trials targeting Aβ have obtained disappointing results, highlighting the complexity of AD pathophysiology and the need for investigating other therapeutic approaches. In this manuscript, we first discuss the challenges associated with anti-Aβ therapies, including limited efficacy and potential adverse effects, underscoring the necessity of exploring alternative mechanisms and targets. Thereafter, we review promising non-Aβ-based strategies, such as tau-targeted therapies, neuroinflammation modulation, and gene and stem cell therapy. These approaches offer new avenues for AD treatment by addressing additional pathological hallmarks and downstream effects beyond Aβ deposition.

Keywords: aducanumab; amyloid; cognitive impairment; dementia; neuroinflammation; tau; therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

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New strategies for AD pharmacological treatment.

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References

    1. Dugger B.N., Dickson D.W. Pathology of Neurodegenerative Diseases. Cold Spring Harb. Perspect. Biol. 2017;9:a028035. doi: 10.1101/cshperspect.a028035. - DOI - PMC - PubMed
    1. Chi H., Chang H.-Y., Sang T.-K. Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. Int. J. Mol. Sci. 2018;19:3082. doi: 10.3390/ijms19103082. - DOI - PMC - PubMed
    1. Noor A., Zafar S., Zerr I. Neurodegenerative Proteinopathies in the Proteoform Spectrum—Tools and Challenges. Int. J. Mol. Sci. 2021;22:1085. doi: 10.3390/ijms22031085. - DOI - PMC - PubMed
    1. Perani D., Caminiti S.P., Carli G., Tondo G. PET Neuroimaging in Dementia Conditions. PET SPECT Neurol. 2021:211–282. doi: 10.1007/978-3-030-53168-3_9. - DOI
    1. Comi C., Tondo G. Insights into the Protective Role of Immunity in Neurodegenerative Disease. Neural Regen. Res. 2017;12:64. doi: 10.4103/1673-5374.198980. - DOI - PMC - PubMed

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Grants and funding

This study was supported by the AGING Project for Department of Excellence at the Department of Translational Medicine (DIMET), Università del Piemonte Orientale, Novara, Italy.

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