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Intermittent fasting modulates human gut microbiota diversity in a phenotype-dependent manner: a systematic review - PubMed

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Intermittent fasting modulates human gut microbiota diversity in a phenotype-dependent manner: a systematic review

Adriyan Pramono et al. Biosci Microbiota Food Health. 2024.

Abstract

Cumulative evidence suggests that intermittent fasting (IF) has beneficial effects on human metabolic health. It has been indicated that its impact on the gut microbiota may mediate these beneficial effects. As a result, we hypothesized that IF may impact the human gut microbiota. A systematic review was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol using the PubMed, Scopus, and CINAHL databases. We registered our systematic review protocol in PROSPERO under registration number CRD42021270050. Human intervention studies published until April 30, 2023, were included. The quality of the included studies was assessed using National Institutes of Health (NIH) quality assessment study tools for intervention studies. The search in the database returned 166 studies, of which 13 matched all criteria for the final qualitative analysis. The body of evidence suggests that IF modulates human gut microbiota alpha and beta diversity in lean (relatively healthy) and relatively healthy overweight/obese individuals but not in individuals with metabolic syndrome. Furthermore, IF also alters human gut microbiota composition in all phenotypes. Of interest, the gut microbiota taxa or microbial metabolites after an IF intervention are associated with metabolic markers. According to this review, IF influences the diversity and taxonomic levels of the human gut microbiota. Individual metabolic phenotypes may alter the effect of IF on the diversity and taxonomic levels of the gut microbiota.

Keywords: diversity; gut microbiota; human; intermittent fasting; systematic review.

©2024 BMFH Press.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.

The PRISMA flow diagram represents the different stages of article selection in this systematic review.

Fig. 2.
Fig. 2.

The gut microbiota diversity as a result of intermittent fasting interventions in humans with different metabolic phenotypes.

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References

    1. Sender R, Fuchs S, Milo R. 2016. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14: e1002533. - PMC - PubMed
    1. Lynch SV, Pedersen O. 2016. The human intestinal microbiome in health and disease. N Engl J Med 375: 2369–2379. - PubMed
    1. Dekaboruah E, Suryavanshi MV, Chettri D, Verma AK. 2020. Human microbiome: an academic update on human body site specific surveillance and its possible role. Arch Microbiol 202: 2147–2167. - PMC - PubMed
    1. Senghor B, Sokhna C, Ruimy R, Lagier JC. 2018. Gut microbiota diversity according to dietary habits and geographical provenance. Hum Microbiome J 7-8: 1–9.
    1. Kashtanova DA, Popenko AS, Tkacheva ON, Tyakht AB, Alexeev DG, Boytsov SA. 2016. Association between the gut microbiota and diet: fetal life, early childhood, and further life. Nutrition 32: 620–627. - PubMed

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