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Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy - PubMed

  • ️Mon Jan 01 2024

Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy

Andreea Despa et al. Vet Sci. 2024.

Abstract

Background: The role of neuroinflammation in epileptogenesis has been previously explored, and several biomarkers have been identified as being relevant in assessing the intensity of the inflammatory process. In human medicine, an increased C reactive protein (CRP) blood concentration and/or neutrophil-to-lymphocyte ratio (NLR) is considered a constant finding of epileptic activity. In veterinary medicine, only a few studies have been published regarding both of these topics.

Hypothesis/objectives: Our aim was to assess the C reactive protein blood concentration and the neutrophil-to-lymphocyte ratio in epileptic dogs, regardless of etiology.

Method: This retrospective study was based on changes in routine blood parameters in 59 dogs with epileptic activity.

Results: An increased C reactive protein concentration was observed mostly in the dogs affected by structural epilepsy, and all epileptic dogs displayed abnormal neutrophil-to-lymphocyte values.

Conclusions: Based on the authors' knowledge, this is the first report regarding the NLR in epileptic dogs. Both the CRP concentration and the NLR might be considered feasible non-specific markers of the neuroinflamation involved in epileptogenesis and might be used in the diagnosis of and therapeutic approach to cluster seizures in dogs with idiopathic epilepsy and in patients with structural epilepsy. Dogs diagnosed with IEis and high CRP concentrations and NLRs may be subject to non-documented cluster seizures. Both CRP and the NLR have limited diagnostic value in dogs with reactive seizures.

Keywords: C reactive protein; canine; epilepsy; inflammation markers; neuroinflammation; neutrophil-to-lymphocyte ratio.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1

Distribution of CRP concentration in the epileptic groups. Three dogs (*, o marks) previously diagnosed with IE had a CRP value out of the group mean ± standard error but no other pathology was identified in their cases.

Figure 2
Figure 2

Distribution of CRP concentration in the idiopathic epilepsy subgroups. Seven dogs (* marks) previously diagnosed with IE with isolated seizures had a CRP value out of the subgroup mean ± standard error but no other pathology was identified in their cases.

Figure 3
Figure 3

Comparison of NLRs in correlation with the etiology of epileptic seizures. Four IE dogs and one with RE (*, o marks) had a NLR value out of the coresponding group mean ± standard error but no other pathology was identified in their cases.

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