Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats - PubMed

• PMID: 3952379
• DOI: 10.1159/000194868

Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats

M Tatár et al. Respiration. 1986.

Abstract

The authors studied the effects of progressive isobaric hypoxia (FO2 = 0.11, 0.07, 0.06, 0.05, 0.04 and 0.03) on respiratory defence reflexes elicited by mechanical stimulation of the airways in 10 pentobarbital-anaesthetized cats. The intensity of the expiration reflex was already significantly reduced at a hypoxia level of only FO2 = 0.11; the intensity of cough also showed a tendency to decrease. The number of efforts and the intensity of both tracheobronchial (TB) and laryngopharyngeal (LPh) cough fell significantly in hypoxia of FO2 = 0.07. On an average, cough could no longer be elicited at PaO2 = 2.0 +/- 0.06 kPa. The aspiration reflex was found to be the most resistant to hypoxia, and could still be elicited just before hypoxic apnoea developed. During hypoxia with FO2 ranging from 0.21 to 0.06, minute ventilation increased, while the intensity of respiratory defence reflexes diminished. TB cough could not be elicited during hypoxia until the breathing was depressed. It can be seen from the results that the regulatory mechanisms responsible for the intensity of respiratory defence reflexes are less resistant to the consequences of an inadequate systemic oxygen supply than the mechanisms controlling ventilation.

Similar articles

• Effect of hypoxia and hypercapina on the airways defence reflexes.

  Tatár M, Tarkanov IA, Korpás J, Kulik AM. Tatár M, et al. Acta Physiol Hung. 1987;70(2-3):195-200. Acta Physiol Hung. 1987. PMID: 3124500

• Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats.

  Jakus J, Stránsky A, Poliacek I, Baráni H, Bosel'ová L. Jakus J, et al. Physiol Res. 1998;47(3):203-13. Physiol Res. 1998. PMID: 9803486

• The expiration reflex from the vocal folds.

  Korpas J, Jakus J. Korpas J, et al. Acta Physiol Hung. 2000;87(3):201-15. doi: 10.1556/APhysiol.87.2000.3.1. Acta Physiol Hung. 2000. PMID: 11428747 Review.

• Laryngeal inputs in defensive airway reflexes in humans.

  Nishino T, Isono S, Tanaka A, Ishikawa T. Nishino T, et al. Pulm Pharmacol Ther. 2004;17(6):377-81. doi: 10.1016/j.pupt.2004.09.013. Pulm Pharmacol Ther. 2004. PMID: 15564079 Review.

Cited by

• Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report.

  Canning BJ, Chang AB, Bolser DC, Smith JA, Mazzone SB, McGarvey L; CHEST Expert Cough Panel. Canning BJ, et al. Chest. 2014 Dec;146(6):1633-1648. doi: 10.1378/chest.14-1481. Chest. 2014. PMID: 25188530 Free PMC article. Review.

• Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.

  Poliacek I, Pitts T, Rose MJ, Davenport PW, Simera M, Veternik M, Kotmanova Z, Bolser DC. Poliacek I, et al. J Neurophysiol. 2017 Jun 1;117(6):2179-2187. doi: 10.1152/jn.00935.2016. Epub 2017 Mar 1. J Neurophysiol. 2017. PMID: 28250153 Free PMC article.

• Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats.

  Poliacek I, Morris KF, Lindsey BG, Segers LS, Rose MJ, Corrie LW, Wang C, Pitts TE, Davenport PW, Bolser DC. Poliacek I, et al. J Appl Physiol (1985). 2011 Sep;111(3):861-73. doi: 10.1152/japplphysiol.00458.2011. Epub 2011 Jun 30. J Appl Physiol (1985). 2011. PMID: 21719729 Free PMC article.

• Cough reflex is additively potentiated by inputs from the laryngeal and tracheobronchial [corrected] receptors and enhanced by stimulation of the central respiratory neurons.

  Kondo T, Hayama N. Kondo T, et al. J Physiol Sci. 2009 Sep;59(5):347-53. doi: 10.1007/s12576-009-0041-y. Epub 2009 Jun 9. J Physiol Sci. 2009. PMID: 19506995 Free PMC article.

• Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?

  Bolser DC, Poliacek I, Jakus J, Fuller DD, Davenport PW. Bolser DC, et al. Respir Physiol Neurobiol. 2006 Jul 28;152(3):255-65. doi: 10.1016/j.resp.2006.01.008. Epub 2006 May 24. Respir Physiol Neurobiol. 2006. PMID: 16723284 Free PMC article. Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • S. Karger AG, Basel, Switzerland

• Miscellaneous

  • NCI CPTAC Assay Portal