Fructose-induced adenine nucleotide catabolism in isolated rat hepatocytes - PubMed

• PMID: 597772
• DOI: 10.1139/o77-185

Fructose-induced adenine nucleotide catabolism in isolated rat hepatocytes

C M Smith et al. Can J Biochem. 1977 Dec.

Abstract

The mechanism of fructose-induced nucleotide catabolism was studied using isolated rat hepatocytes in which the adenine nucleotide pool was prelabelled with [14C]adenine. Incubation of these cells with fructose caused a rapid depletion of the adenine nucleotides and a corresponding increase in allantoin. There was no accumulation of radioactivity in adenosine in the presence or absence of the adenosine deaminase inhibitor 9-erythro-(2-hydroxy-3-nonyl)adenine. This confirms the previous hypothesis that fructose-induced adenine nucleotide catabolism occurs by way of AMP deaminase (AMP amino-hydrolase, EC 3.5.4.6).

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