Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor - PubMed

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor

J Finer-Moore et al. Proc Natl Acad Sci U S A. 1984 Jan.

Abstract

Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.

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