Biguanides. A review of history, pharmacodynamics and therapy - PubMed

• PMID: 6352352

Review

Biguanides. A review of history, pharmacodynamics and therapy

G Schäfer. Diabete Metab. 1983 May-Jun.

Abstract

This review on biguanides gives a general survey of biguanide actions on many metabolic models in vivo and in vitro. It focuses especially on the comparison of the 3 antidiabetic biguanides, of which metformin is discussed as the only oral antidiabetic biguanide useful in treatment of type-II diabetes with a minimum risk of side effects when applied in a well controlled regime. Pharmacokinetics, pharmacodynamics, hypotheses on the molecular mode of action, and implications for therapy are discussed.

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