Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation - PubMed

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• PMID: 7505062
• DOI: 10.1126/science.7505062

Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation

H M Foss et al. Science. 1993.

Erratum in

• Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.

  Foss HM, Roberts CJ, Claeys KM, Selker EU. Foss HM, et al. Science. 1995 Jan 20;267(5196):316. doi: 10.1126/science.7824923. Science. 1995. PMID: 7824923 No abstract available.

Abstract

The function and regulation of DNA methylation in eukaryotes remain unclear. Genes affecting methylation were identified in the fungus Neurospora crassa. A mutation in one gene, dim-2, resulted in the loss of all detectable DNA methylation. Abnormal segregation of the methylation defects in crosses led to the discovery that the methylation mutants frequently generate strains with extra chromosomes or chromosomal parts. Starvation for S-adenosylmethionine, the presumed methyl group donor for DNA methylation, also produced aneuploidy. These results suggest that DNA methylation plays a role in the normal control of chromosome behavior.

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