Perioperative ketorolac tromethamine and postoperative hemorrhage in cases of tonsillectomy and adenoidectomy - PubMed

Perioperative ketorolac tromethamine and postoperative hemorrhage in cases of tonsillectomy and adenoidectomy

J E Gallagher et al. Laryngoscope. 1995 Jun.

Abstract

The charts of 258 patients undergoing tonsillectomy with or without adenoidectomy between June 1991 and June 1993 were reviewed. One hundred sixty-nine of these patients received ketorolac tromethamine during the perioperative period as a nonnarcotic alternative for postoperative pain management. The incidence of postoperative hemorrhage among patients who received ketorolac tromethamine was 10.1%, compared to 2.2% in those patients who received narcotic analgesia only. The average time to adequate oral intake and discharge was evaluated. Ketorolac appeared to moderately decrease the time to adequate oral intake. The use of ketorolac did not significantly alter the time to discharge. The increased incidence of postoperative hemorrhage in patients receiving ketorolac should be considered before this medication is used in the perioperative period. The risk/benefit ratio of ketorolac use as a postoperative analgesic may be better demonstrated in a prospective study.

Similar articles

• Postoperative hemorrhage after tonsillectomy: use of ketorolac tromethamine.

  Agrawal A, Gerson CR, Seligman I, Dsida RM. Agrawal A, et al. Otolaryngol Head Neck Surg. 1999 Mar;120(3):335-9. doi: 10.1016/S0194-5998(99)70271-8. Otolaryngol Head Neck Surg. 1999. PMID: 10064634

• Efficacy and safety of single doses of intramuscular ketorolac tromethamine compared with meperidine for postoperative pain.

  Stanski DR, Cherry C, Bradley R, Sarnquist FH, Yee JP. Stanski DR, et al. Pharmacotherapy. 1990;10(6 ( Pt 2)):40S-44S. Pharmacotherapy. 1990. PMID: 2082312 Clinical Trial.

• Ketorolac, an injectable nonnarcotic analgesic.

  Litvak KM, McEvoy GK. Litvak KM, et al. Clin Pharm. 1990 Dec;9(12):921-35. Clin Pharm. 1990. PMID: 2292174 Review.

• [Ketorolac tromethamine--with special reference to postoperative pain therapy].

  Andersen SS, Jensen ME. Andersen SS, et al. Ugeskr Laeger. 1994 Feb 21;156(8):1160-3. Ugeskr Laeger. 1994. PMID: 8116102 Review. Danish. No abstract available.

Cited by

• Tonsillectomies, ketorolac, and the march of progress.

  Hall SC. Hall SC. Can J Anaesth. 1996 Jun;43(6):544-8. doi: 10.1007/BF03011763. Can J Anaesth. 1996. PMID: 8773857 English, French. No abstract available.

• Minimising the adverse effects of ketorolac.

  Reinhart DI. Reinhart DI. Drug Saf. 2000 Jun;22(6):487-97. doi: 10.2165/00002018-200022060-00007. Drug Saf. 2000. PMID: 10877042 Review.

• Intramuscular ketorolac injections in the athlete.

  Sawyer GA, Anderson BC, Raukar NP, Fadale PD. Sawyer GA, et al. Sports Health. 2012 Jul;4(4):319-27. doi: 10.1177/1941738112439686. Sports Health. 2012. PMID: 23016103 Free PMC article.

• Current guidelines for the treatment of acute pain in children.

  Bhatt-Mehta V. Bhatt-Mehta V. Drugs. 1996 May;51(5):760-76. doi: 10.2165/00003495-199651050-00005. Drugs. 1996. PMID: 8861546 Review.

• Efficacy of ketamine for postoperative pain following robotic thyroidectomy: A prospective randomised study.

  Lee J, Park HP, Jeong MH, Son JD, Kim HC. Lee J, et al. J Int Med Res. 2018 Mar;46(3):1109-1120. doi: 10.1177/0300060517734679. Epub 2017 Nov 10. J Int Med Res. 2018. PMID: 29124992 Free PMC article. Clinical Trial.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Medical

  • MedlinePlus Health Information