Reactivation of hippocampal ensemble memories during sleep - PubMed
- ️Sat Jan 01 1994
. 1994 Jul 29;265(5172):676-9.
doi: 10.1126/science.8036517.
Affiliations
- PMID: 8036517
- DOI: 10.1126/science.8036517
Reactivation of hippocampal ensemble memories during sleep
M A Wilson et al. Science. 1994.
Abstract
Simultaneous recordings were made from large ensembles of hippocampal "place cells" in three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors. Cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks. Cells that were inactive during behavior, or that were active but had non-overlapping spatial firing, did not show this increase. This effect, which declined gradually during each post-behavior sleep session, may result from synaptic modification during waking experience. Information acquired during active behavior is thus re-expressed in hippocampal circuits during sleep, as postulated by some theories of memory consolidation.
Comment in
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Neuroscience. To sleep, perchance to ... learn? New studies say yes.
Barinaga M. Barinaga M. Science. 1994 Jul 29;265(5172):603-4. doi: 10.1126/science.8036508. Science. 1994. PMID: 8036508 No abstract available.
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