Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans - PubMed
Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans
P J Boyle et al. J Clin Invest. 1994 Feb.
Abstract
Systemic glucose utilization declines during sleep in man. We tested the hypothesis that this decline in utilization is largely accounted for by reduced brain glucose metabolism. 10 normal subjects underwent internal jugular and radial artery cannulation to determine cerebral blood flow by N2O equilibrium technique and to quantitate cross-brain glucose and oxygen differences before and every 3 h during sleep. Sleep stage was graded by continuous electroencephalogram, and systemic glucose turnover was estimated by isotope dilution. Brain glucose metabolism fell from 33.6 +/- 2.2 mumol/100 g per min (mean +/- SE) before sleep (2300 h) to a mean nadir of 24.3 +/- 1.1 mumol/100 g per min at 0300 h during sleep (P = 0.001). Corresponding rates of systemic glucose utilization fell from 13.2 +/- 0.8 to 11.0 +/- 0.5 mumol/kg per min (P = 0.003). Diminished brain glucose metabolism was the product of a reduced arteriovenous glucose difference, 0.643 +/- 0.024 to 0.546 +/- 0.020 mmol/liter (P = 0.002), and cerebral blood flow, 50.3 +/- 2.8 to 44.6 +/- 1.4 cc/100 g per min (P = 0.021). Brain oxygen metabolism fell commensurately from 153.4 +/- 11.8 to 128.0 +/- 8.4 mumol/100 g per min (P = 0.045). The observed reduction in brain metabolism occurred independent of stage of central nervous system electrical activity (electroencephalographic data), and was more closely linked to duration of sleep. We conclude that a decline in brain glucose metabolism is a significant determinant of falling rates of systemic glucose utilization during sleep.
Similar articles
-
Lavoie C, Ducros F, Bourque J, Langelier H, Chiasson JL. Lavoie C, et al. Can J Physiol Pharmacol. 1997 Jan;75(1):36-43. Can J Physiol Pharmacol. 1997. PMID: 9101063
-
Lubow JM, Piñón IG, Avogaro A, Cobelli C, Treeson DM, Mandeville KA, Toffolo G, Boyle PJ. Lubow JM, et al. Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E149-E153. doi: 10.1152/ajpendo.00049.2005. Epub 2005 Sep 6. Am J Physiol Endocrinol Metab. 2006. PMID: 16144821
-
Somatostatin enhances insulin-stimulated glucose uptake in the perfused human forearm.
Møller N, Bagger JP, Schmitz O, Jørgensen JO, Ovesen P, Møller J, Alberti KG, Orskov H. Møller N, et al. J Clin Endocrinol Metab. 1995 Jun;80(6):1789-93. doi: 10.1210/jcem.80.6.7775624. J Clin Endocrinol Metab. 1995. PMID: 7775624 Clinical Trial.
-
[Blood circulation and energy metabolism of the brain in healthy sleep].
Hajak G, Klingelhöfer J, Schulz-Varszegi M, Rüther E. Hajak G, et al. Nervenarzt. 1993 Jul;64(7):456-67. Nervenarzt. 1993. PMID: 8366971 Review. German.
-
Cerebral blood flow regulation in REM sleep: a model for flow-metabolism coupling.
Lenzi P, Zoccoli G, Walker AM, Franzini C. Lenzi P, et al. Arch Ital Biol. 1999 May;137(2-3):165-79. Arch Ital Biol. 1999. PMID: 10349495 Review.
Cited by
-
Byun JI, Cha KS, Jun JE, Kim TJ, Jung KY, Jeong IK, Shin WC. Byun JI, et al. Sci Rep. 2020 Oct 21;10(1):17877. doi: 10.1038/s41598-020-74908-x. Sci Rep. 2020. PMID: 33087786 Free PMC article.
-
Byczkowicz N, Eshra A, Montanaro J, Trevisiol A, Hirrlinger J, Kole MH, Shigemoto R, Hallermann S. Byczkowicz N, et al. Elife. 2019 Sep 9;8:e42766. doi: 10.7554/eLife.42766. Elife. 2019. PMID: 31496517 Free PMC article.
-
Hodkinson DJ, O'Daly O, Zunszain PA, Pariante CM, Lazurenko V, Zelaya FO, Howard MA, Williams SC. Hodkinson DJ, et al. J Cereb Blood Flow Metab. 2014 Sep;34(9):1493-9. doi: 10.1038/jcbfm.2014.109. Epub 2014 Jun 18. J Cereb Blood Flow Metab. 2014. PMID: 24938404 Free PMC article. Clinical Trial.
-
Levy WB, Calvert VG. Levy WB, et al. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2008173118. doi: 10.1073/pnas.2008173118. Proc Natl Acad Sci U S A. 2021. PMID: 33906943 Free PMC article.
-
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E. Vlahoyiannis A, et al. Nutrients. 2021 Apr 14;13(4):1283. doi: 10.3390/nu13041283. Nutrients. 2021. PMID: 33919698 Free PMC article.