Cytokine-mediated regulation of intestinal helminth infections: the Trichuris muris model - PubMed

Review

Cytokine-mediated regulation of intestinal helminth infections: the Trichuris muris model

R K Grencis. Ann Trop Med Parasitol. 1993 Dec.

Abstract

The Trichuris muris-mouse model of intestinal helminth infection provides a convenient system to examine the immune mechanisms operating during acute and chronic infection. Particular subsets of helper T lymphocytes (CD4+Th cells) play an important role in regulating infection via the secretion of distinct groups of cytokines. Reciprocal activation of Th cell subsets is associated with either expulsion of the parasites from the intestine (Th2 cells) or chronic infection (Th1 cells). In vivo neutralization experiments using anti-cytokine monoclonal antibodies show that critical cytokines are involved, with interferon-gamma playing an important role in the establishment of chronic trichuriasis and interleukin-4 in expulsion of the parasite from the gut. This model has provided clear evidence of a crucial role for distinct cytokines in mediating host protection against intestinal helminth infection and that manipulation of the immune response through the Th cell-cytokine axis can benefit either the host or the parasite. As such, the T. muris model is poised to generate important new data relevant not only to intestinal helminthiasis but to the wider field of parasite immunity and infection in general.

Similar articles

• Cytokine-mediated regulation of chronic intestinal helminth infection.

  Else KJ, Finkelman FD, Maliszewski CR, Grencis RK. Else KJ, et al. J Exp Med. 1994 Jan 1;179(1):347-51. doi: 10.1084/jem.179.1.347. J Exp Med. 1994. PMID: 8270879 Free PMC article.

• Cytokine regulation of resistance and susceptibility to intestinal nematode infection - from host to parasite.

  Grencis RK. Grencis RK. Vet Parasitol. 2001 Sep 12;100(1-2):45-50. doi: 10.1016/s0304-4017(01)00482-4. Vet Parasitol. 2001. PMID: 11522405 Review.

• Whipworm Infection Promotes Bacterial Invasion, Intestinal Microbiota Imbalance, and Cellular Immunomodulation.

  Schachter J, Alvarinho de Oliveira D, da Silva CM, de Barros Alencar ACM, Duarte M, da Silva MMP, Ignácio ACPR, Lopes-Torres EJ. Schachter J, et al. Infect Immun. 2020 Feb 20;88(3):e00642-19. doi: 10.1128/IAI.00642-19. Print 2020 Feb 20. Infect Immun. 2020. PMID: 31843966 Free PMC article.

• The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection.

  Cliffe LJ, Grencis RK. Cliffe LJ, et al. Adv Parasitol. 2004;57:255-307. doi: 10.1016/S0065-308X(04)57004-5. Adv Parasitol. 2004. PMID: 15504540 Review.

Cited by

• Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.

  Montaño KJ, Cuéllar C, Sotillo J. Montaño KJ, et al. Front Cell Infect Microbiol. 2021 Apr 22;11:639573. doi: 10.3389/fcimb.2021.639573. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33968800 Free PMC article. Review.

• Muc5ac: a critical component mediating the rejection of enteric nematodes.

  Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Hasnain SZ, et al. J Exp Med. 2011 May 9;208(5):893-900. doi: 10.1084/jem.20102057. Epub 2011 Apr 18. J Exp Med. 2011. PMID: 21502330 Free PMC article.

• Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.

  Brady MT, O'Neill SM, Dalton JP, Mills KH. Brady MT, et al. Infect Immun. 1999 Oct;67(10):5372-8. doi: 10.1128/IAI.67.10.5372-5378.1999. Infect Immun. 1999. PMID: 10496919 Free PMC article.

• Lactobacillus rhamnosus ingestion promotes innate host defense in an enteric parasitic infection.

  McClemens J, Kim JJ, Wang H, Mao YK, Collins M, Kunze W, Bienenstock J, Forsythe P, Khan WI. McClemens J, et al. Clin Vaccine Immunol. 2013 Jun;20(6):818-26. doi: 10.1128/CVI.00047-13. Epub 2013 Mar 27. Clin Vaccine Immunol. 2013. PMID: 23536695 Free PMC article.

• Host age, sex, and reproductive seasonality affect nematode parasitism in wild Japanese macaques.

  MacIntosh AJ, Hernandez AD, Huffman MA. MacIntosh AJ, et al. Primates. 2010 Oct;51(4):353-64. doi: 10.1007/s10329-010-0211-9. Epub 2010 Aug 14. Primates. 2010. PMID: 20711744

Publication types

MeSH terms

Substances

LinkOut - more resources

• Research Materials

  • NCI CPTC Antibody Characterization Program