Effects of beta-carotene supplementation on lipid peroxidation in humans - PubMed
Clinical Trial
Effects of beta-carotene supplementation on lipid peroxidation in humans
J P Allard et al. Am J Clin Nutr. 1994 Apr.
Abstract
The ability of beta-carotene (BC) to reduce lipid peroxidation in humans was investigated. In this randomized double-blind controlled trial, 42 nonsmokers and 28 smokers received either 20 mg BC or placebo daily for 4 wk. Twenty-five smokers and 38 nonsmokers completed the trial. Changes in plasma BC concentrations increased significantly (P < 0.0005) and to the same extent in both groups supplemented with BC. There were no significant changes among the placebo groups. At baseline, lipid peroxidation measured by breath-pentane output (BPO) was significantly higher in the two smoking groups (BC: 8.8 +/- 1.1, placebo: 9.4 +/- 1.4 pmol.kg-1.min-1) than in the two nonsmoking groups (BC: 5.7 +/- 0.5, placebo: 5.9 +/- 0.6 pmol.kg-1.min-1) (P < 0.005). BPO decreased significantly only in smokers receiving BC (6.5 +/- 0.7 pmol.kg-1.min-1) (P < 0.04). Changes in breath-ethane output were not significant. Therefore, lipid peroxidation measured by BPO is significantly higher in smokers than in nonsmokers and is reduced by BC supplementation in smokers. There was no significant change (95% CI - 1.26, 1.12) in BPO when nonsmokers received BC.
Similar articles
-
Exhaled ethane and antioxidant vitamin supplements in active smokers.
Do BK, Garewal HS, Clements NC Jr, Peng YM, Habib MP. Do BK, et al. Chest. 1996 Jul;110(1):159-64. doi: 10.1378/chest.110.1.159. Chest. 1996. PMID: 8681621
-
Vitamin E suppresses increased lipid peroxidation in cigarette smokers.
Hoshino E, Shariff R, Van Gossum A, Allard JP, Pichard C, Kurian R, Jeejeebhoy KN. Hoshino E, et al. JPEN J Parenter Enteral Nutr. 1990 May-Jun;14(3):300-5. doi: 10.1177/0148607190014003300. JPEN J Parenter Enteral Nutr. 1990. PMID: 2352340
-
Oxidative stress in smokers supplemented with vitamin C.
Aghdassi E, Royall D, Allard JP. Aghdassi E, et al. Int J Vitam Nutr Res. 1999 Jan;69(1):45-51. doi: 10.1024/0300-9831.69.1.45. Int J Vitam Nutr Res. 1999. PMID: 10052021 Clinical Trial.
-
Breath alkanes as a marker of oxidative stress in different clinical conditions.
Aghdassi E, Allard JP. Aghdassi E, et al. Free Radic Biol Med. 2000 Mar 15;28(6):880-6. doi: 10.1016/s0891-5849(00)00189-1. Free Radic Biol Med. 2000. PMID: 10802218 Review.
-
Omaye ST, Krinsky NI, Kagan VE, Mayne ST, Liebler DC, Bidlack WR. Omaye ST, et al. Fundam Appl Toxicol. 1997 Dec;40(2):163-74. doi: 10.1006/faat.1997.2387. Fundam Appl Toxicol. 1997. PMID: 9441712 Review.
Cited by
-
Beta-carotene intake and risk of nonfatal acute myocardial infarction in women.
Tavani A, Negri E, D'Avanzo B, La Vecchia C. Tavani A, et al. Eur J Epidemiol. 1997 Sep;13(6):631-7. doi: 10.1023/a:1007376901183. Eur J Epidemiol. 1997. PMID: 9324208
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Bjelakovic G, et al. Cochrane Database Syst Rev. 2012 Mar 14;2012(3):CD007176. doi: 10.1002/14651858.CD007176.pub2. Cochrane Database Syst Rev. 2012. PMID: 22419320 Free PMC article. Review.
-
Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity.
Pryor WA. Pryor WA. Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):875-82. doi: 10.1289/ehp.97105s4875. Environ Health Perspect. 1997. PMID: 9255574 Free PMC article. Review.
-
Effects of dietary nutrients on volatile breath metabolites.
Ajibola OA, Smith D, Spaněl P, Ferns GA. Ajibola OA, et al. J Nutr Sci. 2013 Oct 31;2:e34. doi: 10.1017/jns.2013.26. eCollection 2013. J Nutr Sci. 2013. PMID: 25191584 Free PMC article.
-
Carotenoids from Marine Organisms: Biological Functions and Industrial Applications.
Galasso C, Corinaldesi C, Sansone C. Galasso C, et al. Antioxidants (Basel). 2017 Nov 23;6(4):96. doi: 10.3390/antiox6040096. Antioxidants (Basel). 2017. PMID: 29168774 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous