Oral cytidine 5'-diphosphate choline administration to rats increases brain phospholipid levels - PubMed

Oral cytidine 5'-diphosphate choline administration to rats increases brain phospholipid levels

J Agut et al. Ann N Y Acad Sci. 1993.

Abstract

Exogenous cytidine 5'diphosphocholine (CDP-choline) is completely metabolized to circulating cytidine and choline. Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. We administered oral CDP-choline to 12 month-old rats (500 mg/kg/day) for 21, 42, or 90 days to determine whether this treatment would alter brain levels of PC and the other structural phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE). After 42 days, brain PC levels increased significantly (p < 0.01) by 23.3%; after 90 days PC increased by 30% (p < 0.01), PS by 37.2% (p < 0.01), and PE by 13% (not significant). The ratios of each of the phospholipids to total membrane phospholipids were unchanged. These data demonstrate that repeated oral CDP-choline administration can increase the amounts of phospholipids in brain membranes, thus providing a rationale for using this compound in brain diseases that damage neurons.

Similar articles

• Evidence that 5'-cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels.

  López-Coviella I, Agut J, Savci V, Ortiz JA, Wurtman RJ. López-Coviella I, et al. J Neurochem. 1995 Aug;65(2):889-94. doi: 10.1046/j.1471-4159.1995.65020889.x. J Neurochem. 1995. PMID: 7616250

• Radioactivity incorporation into different cerebral phospholipids after oral administration of 14C methyl CDP-choline.

  Agut J, Font E, Sacristán A, Ortiz JA. Agut J, et al. Arzneimittelforschung. 1983;33(7A):1048-50. Arzneimittelforschung. 1983. PMID: 6684464

• Effects of orally administered cytidine 5'-diphosphate choline on brain phospholipid content.

  López G-Coviella I, Agut J, Ortiz JA, Wurtman RJ. López G-Coviella I, et al. J Nutr Biochem. 1992 Jun;3(6):313-5. doi: 10.1016/0955-2863(92)90039-l. J Nutr Biochem. 1992. PMID: 11537628

• Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline.

  Weiss GB. Weiss GB. Life Sci. 1995;56(9):637-60. doi: 10.1016/0024-3205(94)00427-t. Life Sci. 1995. PMID: 7869846 Review.

• From yeast to humans - roles of the Kennedy pathway for phosphatidylcholine synthesis.

  McMaster CR. McMaster CR. FEBS Lett. 2018 Apr;592(8):1256-1272. doi: 10.1002/1873-3468.12919. Epub 2017 Dec 19. FEBS Lett. 2018. PMID: 29178478 Review.

Cited by

• Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review.

  Mulder IA, van Bavel ET, de Vries HE, Coutinho JM. Mulder IA, et al. Fluids Barriers CNS. 2021 Oct 19;18(1):46. doi: 10.1186/s12987-021-00280-1. Fluids Barriers CNS. 2021. PMID: 34666786 Free PMC article.

• Citicoline protects against cognitive impairment in a rat model of chronic cerebral hypoperfusion.

  Lee HJ, Kang JS, Kim YI. Lee HJ, et al. J Clin Neurol. 2009 Mar;5(1):33-8. doi: 10.3988/jcn.2009.5.1.33. Epub 2008 Mar 31. J Clin Neurol. 2009. PMID: 19513332 Free PMC article.

• Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy.

  Sun MS, Jin H, Sun X, Huang S, Zhang FL, Guo ZN, Yang Y. Sun MS, et al. Oxid Med Cell Longev. 2018 Jan 31;2018:3804979. doi: 10.1155/2018/3804979. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29770166 Free PMC article. Review.

• Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.

  Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Wang L, et al. J Mol Neurosci. 2005;27(1):137-45. doi: 10.1385/JMN:27:1:137. J Mol Neurosci. 2005. PMID: 16055952

• Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats.

  Rema V, Bali KK, Ramachandra R, Chugh M, Darokhan Z, Chaudhary R. Rema V, et al. Neuroscience. 2008 Aug 13;155(2):556-64. doi: 10.1016/j.neuroscience.2008.04.017. Epub 2008 Apr 16. Neuroscience. 2008. PMID: 18619738 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database