The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme - PubMed

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• PMID: 8242740
• DOI: 10.1016/0092-8674(93)90485-9

Comparative Study

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

J Yuan et al. Cell. 1993.

Abstract

We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic brain. The sequences of 12 ced-3 mutations as well as the sequences of ced-3 genes from two related nematode species identify sites of potential functional importance. We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals.

Comment in

• A first insight into the molecular mechanisms of apoptosis.

  Yuan J, Horvitz HR. Yuan J, et al. Cell. 2004 Jan 23;116(2 Suppl):S53-6, 1 p following S59. doi: 10.1016/s0092-8674(04)00028-5. Cell. 2004. PMID: 15055582 No abstract available.

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