The humoral antibacterial response of Drosophila - PubMed

Affiliations

• PMID: 8513894
• DOI: 10.1016/0014-5793(93)81414-u

Free article

Review

The humoral antibacterial response of Drosophila

J A Hoffmann et al. FEBS Lett. 1993.

Free article

Abstract

Drosophila, like other insects, responds to the injection of bacteria by the rapid and transient synthesis of a battery of potent antibacterial peptides. Only a few of these peptides have been fully characterized to date. We review our recent data on the control of the expression of a gene encoding one of the induced peptides, i.e. diptericin. Our data highlight the role of proximal cis-regulatory motifs similar to regulatory elements binding NF-kappa B and NF-IL6 in promoters of some immune genes of mammals. We argue that the Drosophila host defense is homologous to the mammalian acute phase response.

Similar articles

• Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter.

  Meister M, Braun A, Kappler C, Reichhart JM, Hoffmann JA. Meister M, et al. EMBO J. 1994 Dec 15;13(24):5958-66. doi: 10.1002/j.1460-2075.1994.tb06941.x. EMBO J. 1994. PMID: 7813433 Free PMC article.

• Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.

  Georgel P, Meister M, Kappler C, Lemaitre B, Reichhart JM, Hoffmann JA. Georgel P, et al. Biochem Biophys Res Commun. 1993 Dec 15;197(2):508-17. doi: 10.1006/bbrc.1993.2508. Biochem Biophys Res Commun. 1993. PMID: 7505569

• Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter.

  Georgel P, Kappler C, Langley E, Gross I, Nicolas E, Reichhart JM, Hoffmann JA. Georgel P, et al. Nucleic Acids Res. 1995 Apr 11;23(7):1140-5. doi: 10.1093/nar/23.7.1140. Nucleic Acids Res. 1995. PMID: 7537872 Free PMC article.

• Molecular genetics of Drosophila immunity.

  Ip YT, Levine M. Ip YT, et al. Curr Opin Genet Dev. 1994 Oct;4(5):672-7. doi: 10.1016/0959-437x(94)90133-n. Curr Opin Genet Dev. 1994. PMID: 7849506 Review.

• Induction and regulation of antimicrobial peptides in Drosophila.

  Engström Y. Engström Y. Dev Comp Immunol. 1999 Jun-Jul;23(4-5):345-58. doi: 10.1016/s0145-305x(99)00016-6. Dev Comp Immunol. 1999. PMID: 10426427 Review.

Cited by

• Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

  Diamond G, Russell JP, Bevins CL. Diamond G, et al. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5156-60. doi: 10.1073/pnas.93.10.5156. Proc Natl Acad Sci U S A. 1996. PMID: 8643545 Free PMC article.

• The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid.

  Manners JM, Penninckx IA, Vermaere K, Kazan K, Brown RL, Morgan A, Maclean DJ, Curtis MD, Cammue BP, Broekaert WF. Manners JM, et al. Plant Mol Biol. 1998 Dec;38(6):1071-80. doi: 10.1023/a:1006070413843. Plant Mol Biol. 1998. PMID: 9869413

• Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter.

  Meister M, Braun A, Kappler C, Reichhart JM, Hoffmann JA. Meister M, et al. EMBO J. 1994 Dec 15;13(24):5958-66. doi: 10.1002/j.1460-2075.1994.tb06941.x. EMBO J. 1994. PMID: 7813433 Free PMC article.

• Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.

  Lemaitre B, Meister M, Govind S, Georgel P, Steward R, Reichhart JM, Hoffmann JA. Lemaitre B, et al. EMBO J. 1995 Feb 1;14(3):536-45. doi: 10.1002/j.1460-2075.1995.tb07029.x. EMBO J. 1995. PMID: 7859742 Free PMC article.

• Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds.

  Pfalzgraff A, Brandenburg K, Weindl G. Pfalzgraff A, et al. Front Pharmacol. 2018 Mar 28;9:281. doi: 10.3389/fphar.2018.00281. eCollection 2018. Front Pharmacol. 2018. PMID: 29643807 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase