A model of host-microbial interactions in an open mammalian ecosystem - PubMed

A model of host-microbial interactions in an open mammalian ecosystem

L Bry et al. Science. 1996.

Abstract

The maintenance and significance of the complex populations of microbes present in the mammalian intestine are poorly understood. Comparison of conventionally housed and germ-free NMRI mice revealed that production of fucosylated glycoconjugates and an alpha1, 2-fucosyltransferase messenger RNA in the small-intestinal epithelium requires the normal microflora. Colonization of germ-free mice with Bacteroides thetaiotaomicron, a component of this flora, restored the fucosylation program, whereas an isogenic strain carrying a transposon insertion that disrupts its ability to use L-fucose as a carbon source did not. Simplified models such as this should aid the study of open microbial ecosystems.

Comment in

• Interactions between epithelial cells and bacteria, normal and pathogenic.

  Umesaki Y, Okada Y, Imaoka A, Setoyama H, Matsumoto S. Umesaki Y, et al. Science. 1997 May 9;276(5314):964-5. doi: 10.1126/science.276.5314.964. Science. 1997. PMID: 9139662 No abstract available.

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