Epidemiology of Alzheimer's disease and current possibilities for prevention - PubMed

Review

Epidemiology of Alzheimer's disease and current possibilities for prevention

L Fratiglioni. Acta Neurol Scand Suppl. 1996.

Abstract

Many epidemiological studies of Alzheimer's disease (AD) have been conducted. This review discusses the most recent findings in relation to the possibilities of prevention of this disease. Data on the diagnostic validity are also reported. The primary prevention of AD is hampered by limitations in the knowledge and understanding about its risk factors. Among the factors that have been investigated, only age, familial aggregation, and apolipoprotein E gene-e4 allele are definite risk factors both for early- and late-onset AD. However, many of the possible and putative risk factors, if definitely confirmed, can be prevented or controlled. Secondary prevention is not currently practicable as valid predictive tests and efficacious treatment are lacking. In contrast, much data is available to support tertiary prevention interventions, such as better planned patient care.

Similar articles

• Alzheimer's disease prevention: from risk factors to early intervention.

  Crous-Bou M, Minguillón C, Gramunt N, Molinuevo JL. Crous-Bou M, et al. Alzheimers Res Ther. 2017 Sep 12;9(1):71. doi: 10.1186/s13195-017-0297-z. Alzheimers Res Ther. 2017. PMID: 28899416 Free PMC article. Review.

• [Risk factors of Alzheimer's disease. Epidemiologic approach].

  Alpérovitch A, Berr C. Alpérovitch A, et al. Bull Acad Natl Med. 1996 Oct;180(7):1673-80; discussion 1680-5. Bull Acad Natl Med. 1996. PMID: 9102150 Review. French.

• Epidemiological of and risk factors for Alzheimer's disease: a review.

  Povova J, Ambroz P, Bar M, Pavukova V, Sery O, Tomaskova H, Janout V. Povova J, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Jun;156(2):108-14. doi: 10.5507/bp.2012.055. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012. PMID: 22837131 Review.

• Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.

  Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DM. Davidson Y, et al. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):515-7. doi: 10.1136/jnnp.2005.063917. J Neurol Neurosurg Psychiatry. 2006. PMID: 16543533 Free PMC article.

• Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.

  Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ. Lehtovirta M, et al. Neurology. 1996 Feb;46(2):413-9. doi: 10.1212/wnl.46.2.413. Neurology. 1996. PMID: 8614504

Cited by

• The role of early-life educational quality and literacy in explaining racial disparities in cognition in late life.

  Sisco S, Gross AL, Shih RA, Sachs BC, Glymour MM, Bangen KJ, Benitez A, Skinner J, Schneider BC, Manly JJ. Sisco S, et al. J Gerontol B Psychol Sci Soc Sci. 2015 Jul;70(4):557-67. doi: 10.1093/geronb/gbt133. Epub 2014 Feb 28. J Gerontol B Psychol Sci Soc Sci. 2015. PMID: 24584038 Free PMC article.

• Advances in the treatment of visual hallucinations in neurodegenerative diseases.

  Collerton D, Taylor JP. Collerton D, et al. Future Neurol. 2013 Jul;8(4):433-444. doi: 10.2217/fnl.13.19. Future Neurol. 2013. PMID: 23882162 Free PMC article.

• Estrogen regulation of the neprilysin gene through a hormone-responsive element.

  Xiao ZM, Sun L, Liu YM, Zhang JJ, Huang J. Xiao ZM, et al. J Mol Neurosci. 2009 Sep;39(1-2):22-6. doi: 10.1007/s12031-008-9168-1. Epub 2009 Jan 6. J Mol Neurosci. 2009. PMID: 19127446

• Dementia / Alzheimer's Disease.

  Lindsay J, Anderson L. Lindsay J, et al. BMC Womens Health. 2004 Aug 25;4 Suppl 1(Suppl 1):S20. doi: 10.1186/1472-6874-4-S1-S20. BMC Womens Health. 2004. PMID: 15345083 Free PMC article.

• Using artificial intelligence to learn optimal regimen plan for Alzheimer's disease.

  Bhattarai K, Rajaganapathy S, Das T, Kim Y, Chen Y; Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing; Dai Q, Li X, Jiang X, Zong N. Bhattarai K, et al. J Am Med Inform Assoc. 2023 Sep 25;30(10):1645-1656. doi: 10.1093/jamia/ocad135. J Am Med Inform Assoc. 2023. PMID: 37463858 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Medical

  • MedlinePlus Health Information