pubmed.ncbi.nlm.nih.gov

A coronary primary intervention study of Japanese men: study design, implementation and baseline data. The Kyushu Lipid Intervention Study Group - PubMed

Clinical Trial

A coronary primary intervention study of Japanese men: study design, implementation and baseline data. The Kyushu Lipid Intervention Study Group

No authors listed. J Atheroscler Thromb. 1996.

Abstract

This report describes the design and baseline results of the Kyushu Lipid Intervention Study (KLIS). The study aims to test the hypothesis that the long term reduction of serum total cholesterol by pravastatin will lead to a decrease in coronary heart disease (CHD) events. The trial was designed to include a random 6,000 male patients aged 45-74 years with serum total cholesterol of 220 mg/dl (5.69 mmol/l) or greater and without a history of myocardial infarction, coronary surgery or angioplasty, to undertake either pravastatin or conventional treatment (including hypolipidemic drugs other than HMG CoA reductase inhibitors, probucol and bezafibrate), and to follow up each patient for 5 years. Primary endpoints are fatal and nonfatal myocardial infarction, coronary bypass surgery and angioplasty, cardiac death, and sudden and unexpected death. During the period from May 1990 to September 1993, a total of 5,640 male patients aged 45-74 were recruited by 902 participating physicians throughout Kyushu. Randomization was, however, neglected by study physicians; the numbers of patients enrolled were 3,061 in the pravastatin group and 2,579 in the conventional treatment group. Patients allocated to the pravastatin treatment were generally unfavorable regarding coronary risk factors. Baseline mean levels of serum total cholesterol were 259 mg/dl (6.70 mmol/l) in the pravastatin group and 246 mg/dl (6.36 mmol/l) in the conventional treatment group (p <0.001). Although the trial was regarded as a prospective observational study, the KLIS provides valuable quantitative data regarding cholesterol lowering and reduction in CHD events as well as safety data of the long-term use of a statin in Japanese men with hypercholesterolemia.

PubMed Disclaimer

Cited by

Does pravastatin promote cancer in elderly patients? A meta-analysis.
Bonovas S, Sitaras NM. Bonovas S, et al. CMAJ. 2007 Feb 27;176(5):649-54. doi: 10.1503/cmaj.060803. CMAJ. 2007. PMID: 17325332 Free PMC article.
Statins for the primary prevention of cardiovascular disease.
Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S. Taylor F, et al. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD004816. doi: 10.1002/14651858.CD004816.pub5. Cochrane Database Syst Rev. 2013. PMID: 23440795 Free PMC article. Review.
Use of lipid lowering drugs for primary prevention of coronary heart disease: meta-analysis of randomised trials.
Pignone M, Phillips C, Mulrow C. Pignone M, et al. BMJ. 2000 Oct 21;321(7267):983-6. doi: 10.1136/bmj.321.7267.983. BMJ. 2000. PMID: 11039962 Free PMC article.
Statins for the primary prevention of cardiovascular disease.
Taylor F, Ward K, Moore TH, Burke M, Davey Smith G, Casas JP, Ebrahim S. Taylor F, et al. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD004816. doi: 10.1002/14651858.CD004816.pub4. Cochrane Database Syst Rev. 2011. PMID: 21249663 Free PMC article. Updated. Review.

A coronary primary intervention study of Japanese men: study design, implementation and baseline data. The Kyushu Lipid Intervention Study Group - PubMed