Homeosis and polyposis: a tale from the mouse - PubMed

Review

Homeosis and polyposis: a tale from the mouse

T C He et al. Bioessays. 1997 Jul.

Abstract

Homeobox genes play essential roles in specifying the fates of different cell types during embryogenesis. In Drosophila, the homeotic gene caudal is important for the generation of posterior structures. In the mouse, the caudal homologue Cdx2 has been implicated in directing early processes in intestinal morphogenesis and in the maintenance of the differentiated phenotype. A recent study showed that Cdx2 null mutation was embryonically lethal, whereas Cdx2+/- mice developed multiple intestinal polyps in the proximal colon in addition to developmental defects. There are striking phenotypic similarities and differences between Cdx2+/- and other mice predisposed to intestinal neoplasia. The possible role of Cdx2 in human colorectal tumorigenesis is discussed.

Similar articles

• Homeosis and intestinal tumours in Cdx2 mutant mice.

  Chawengsaksophak K, James R, Hammond VE, Köntgen F, Beck F. Chawengsaksophak K, et al. Nature. 1997 Mar 6;386(6620):84-7. doi: 10.1038/386084a0. Nature. 1997. PMID: 9052785

• The Cdx-1 and Cdx-2 homeobox genes in the intestine.

  Freund JN, Domon-Dell C, Kedinger M, Duluc I. Freund JN, et al. Biochem Cell Biol. 1998;76(6):957-69. doi: 10.1139/o99-001. Biochem Cell Biol. 1998. PMID: 10392709 Review.

• Cloning and chromosome assignment of the human CDX2 gene.

  Drummond F, Putt W, Fox M, Edwards YH. Drummond F, et al. Ann Hum Genet. 1997 Sep;61(Pt 5):393-400. doi: 10.1046/j.1469-1809.1997.6150393.x. Ann Hum Genet. 1997. PMID: 9459001

• CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer.

  Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B. Wicking C, et al. Oncogene. 1998 Aug 6;17(5):657-9. doi: 10.1038/sj.onc.1201971. Oncogene. 1998. PMID: 9704932

• Sequence and functional properties of Ets genes in the model organism Drosophila.

  Hsu T, Schulz RA. Hsu T, et al. Oncogene. 2000 Dec 18;19(55):6409-16. doi: 10.1038/sj.onc.1204033. Oncogene. 2000. PMID: 11175357 Review.

Cited by

• Identification and comparative analysis of human colonocyte short-chain fatty acid response genes.

  Basson MD, Liu YW, Hanly AM, Emenaker NJ, Shenoy SG, Gould Rothberg BE. Basson MD, et al. J Gastrointest Surg. 2000 Sep-Oct;4(5):501-12. doi: 10.1016/s1091-255x(00)80093-1. J Gastrointest Surg. 2000. PMID: 11077326

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • FlyBase
  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program