A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB - PubMed
- ️Wed Jan 01 1997
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
J A DiDonato et al. Nature. 1997.
Abstract
Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein kinase complex, IKK (for IkappaB kinase), has now been purified that phosphorylates IkappaBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.
Comment in
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Signal transduction. IkappaB kinase all zipped up.
Israël A. Israël A. Nature. 1997 Aug 7;388(6642):519-21. doi: 10.1038/41433. Nature. 1997. PMID: 9252183 No abstract available.
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