Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria - PubMed

Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria

S Kernéis et al. Science. 1997.

Abstract

The epithelium that lines the gut is impermeable to macromolecules and microorganisms, except in Peyer's patches (PPs), where the lymphoid follicle-associated epithelium (FAE) contains M cells that transport antigens and microorganisms. A cultured system that reproduces the main characteristics of FAE and M cells was established by cultivation of PP lymphocytes with the differentiated human intestinal cell line Caco-2. Lymphocytes settled into the epithelial monolayer, inducing reorganization of the brush border and a temperature-dependent transport of particles and Vibrio cholerae. This model system could prove useful for intestinal physiology, vaccine research, and drug delivery studies.

Comment in

• The chameleon within: improving antigen delivery.

  Madara JL. Madara JL. Science. 1997 Aug 15;277(5328):910-1. doi: 10.1126/science.277.5328.910. Science. 1997. PMID: 9281072 No abstract available.

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