Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene - PubMed

Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene

J J Lin et al. Gene. 1998.

Abstract

Subtraction hybridization using a cDNA library prepared from temporally spaced mRNAs from human melanoma cells treated with recombinant human fibroblast interferon (IFN-beta) plus mezerein (MEZ) that induces terminal differentiation (tester cDNA library) and a temporally spaced cDNA library prepared from actively proliferating melanoma cells (driver cDNA library) produced a Temporally Spaced Subtracted (TSS) cDNA library. This approach resulted in the identification of melanoma differentiation associated (mda) genes displaying both enhanced and suppressed expression during growth inhibition and differentiation. In the present report, we describe a novel cDNA mda-9 that consists of 2084 nucleotides, and encodes a protein of 298 amino acids with a predicted M(r) of approx. 33 kDa. Treatment of human SV40-immortalized normal melanoma cells with immune interferon, INF-gamma, induces growth suppression and enhances mda-9 expression without inducing terminal differentiation. These results establish that induction of terminal differentiation in human melanoma cells, using the combination of a type I interferon (IFN-beta) + MEZ, can elicit signaling pathways and gene expression changes also regulated by type II immune interferon.

Similar articles

• mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.

  Gupta P, Su ZZ, Lebedeva IV, Sarkar D, Sauane M, Emdad L, Bachelor MA, Grant S, Curiel DT, Dent P, Fisher PB. Gupta P, et al. Pharmacol Ther. 2006 Sep;111(3):596-628. doi: 10.1016/j.pharmthera.2005.11.005. Epub 2006 Feb 7. Pharmacol Ther. 2006. PMID: 16464504 Free PMC article. Review.

• Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.

  Huang EY, Madireddi MT, Gopalkrishnan RV, Leszczyniecka M, Su Z, Lebedeva IV, Kang D, Jiang H, Lin JJ, Alexandre D, Chen Y, Vozhilla N, Mei MX, Christiansen KA, Sivo F, Goldstein NI, Mhashilkar AB, Chada S, Huberman E, Pestka S, Fisher PB. Huang EY, et al. Oncogene. 2001 Oct 25;20(48):7051-63. doi: 10.1038/sj.onc.1204897. Oncogene. 2001. PMID: 11704829

• Differentiation primary response genes and proto-oncogenes as positive and negative regulators of terminal hematopoietic cell differentiation.

  Liebermann DA, Hoffman B. Liebermann DA, et al. Stem Cells. 1994 Jul;12(4):352-69. doi: 10.1002/stem.5530120402. Stem Cells. 1994. PMID: 7951003 Review.

Cited by

• mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.

  Gupta P, Su ZZ, Lebedeva IV, Sarkar D, Sauane M, Emdad L, Bachelor MA, Grant S, Curiel DT, Dent P, Fisher PB. Gupta P, et al. Pharmacol Ther. 2006 Sep;111(3):596-628. doi: 10.1016/j.pharmthera.2005.11.005. Epub 2006 Feb 7. Pharmacol Ther. 2006. PMID: 16464504 Free PMC article. Review.

• Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.

  Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL, Chatterjee D, Pellecchia M, Sarkar D, Fisher PB. Das SK, et al. Cancer Res. 2012 Dec 1;72(23):6217-26. doi: 10.1158/0008-5472.CAN-12-0402. Epub 2012 Oct 11. Cancer Res. 2012. PMID: 23066033 Free PMC article.

• A Paradigm in Immunochemistry, Revealed by Monoclonal Antibodies to Spatially Distinct Epitopes on Syntenin-1.

  Johnson IRD, Sorvina A, Logan JM, Moore CR, Heatlie JK, Parkinson-Lawrence EJ, Selemidis S, O'Leary JJ, Butler LM, Brooks DA. Johnson IRD, et al. Int J Mol Sci. 2019 Nov 29;20(23):6035. doi: 10.3390/ijms20236035. Int J Mol Sci. 2019. PMID: 31795513 Free PMC article.

• Nuclear PI3K signaling in cell growth and tumorigenesis.

  Davis WJ, Lehmann PZ, Li W. Davis WJ, et al. Front Cell Dev Biol. 2015 Apr 13;3:24. doi: 10.3389/fcell.2015.00024. eCollection 2015. Front Cell Dev Biol. 2015. PMID: 25918701 Free PMC article. Review.

• A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy.

  Yu Y, Li S, Wang K, Wan X. Yu Y, et al. Comput Struct Biotechnol J. 2019 Jan 8;17:136-141. doi: 10.1016/j.csbj.2019.01.002. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 30766662 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource