A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation - PubMed

Review

A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation

D R Gallie. Gene. 1998.

Abstract

A quarter of century following the prediction that mRNAs are translated in a circular form, recent biochemical and genetic evidence has accumulated to support the idea that communication between the termini of an mRNA is necessary to promote translation initiation. The poly(A)-binding protein (PABP) interacts with the cap-associated eukaryotic initiation factor (eIF) 4G (in yeast and plants) and eIF4B (in plants), a functional consequence of which is to increase the affinity of PABP for poly(A) and to increase the affinity of the cap-binding complex, eIF4F (of which eIF4G is a subunit) for the 5' cap structure. In mammals, PABP interacts with a novel PABP-interacting protein that also binds eIF4A. The interaction between PABP and those initiation factors associated with the 5' terminus of an mRNA may also explain the role of PABP during mRNA turnover, as it protects the 5' cap from attack by Dcp1p, the decapping enzyme. Several of those mRNAs that have evolved functional equivalents to a cap or a poly(A) tail nevertheless require a functional interaction between terminal regulatory elements similar to that observed between the 5' cap and poly(A) tail, suggesting that efficient translation is predicated on communication between largely-separated regulatory elements within an mRNA.

Similar articles

• Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.

  Craig AW, Haghighat A, Yu AT, Sonenberg N. Craig AW, et al. Nature. 1998 Apr 2;392(6675):520-3. doi: 10.1038/33198. Nature. 1998. PMID: 9548260

• Competitive and noncompetitive binding of eIF4B, eIF4A, and the poly(A) binding protein to wheat translation initiation factor eIFiso4G.

  Cheng S, Gallie DR. Cheng S, et al. Biochemistry. 2010 Sep 28;49(38):8251-65. doi: 10.1021/bi1008529. Biochemistry. 2010. PMID: 20795652

• A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.

  Imataka H, Gradi A, Sonenberg N. Imataka H, et al. EMBO J. 1998 Dec 15;17(24):7480-9. doi: 10.1093/emboj/17.24.7480. EMBO J. 1998. PMID: 9857202 Free PMC article.

• Regulation of poly(A)-binding protein through PABP-interacting proteins.

  Derry MC, Yanagiya A, Martineau Y, Sonenberg N. Derry MC, et al. Cold Spring Harb Symp Quant Biol. 2006;71:537-43. doi: 10.1101/sqb.2006.71.061. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381337 Review.

• [Translational control by the poly(A) binding protein: a check for mRNA integrity].

  Svitkin YV, Sonenberg N. Svitkin YV, et al. Mol Biol (Mosk). 2006 Jul-Aug;40(4):684-93. Mol Biol (Mosk). 2006. PMID: 16913227 Review. Russian.

Cited by

• Analysis of the Tomato spotted wilt virus ambisense S RNA-encoded hairpin structure in translation.

  Geerts-Dimitriadou C, Lu YY, Geertsema C, Goldbach R, Kormelink R. Geerts-Dimitriadou C, et al. PLoS One. 2012;7(2):e31013. doi: 10.1371/journal.pone.0031013. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363535 Free PMC article.

• So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes.

  Slobodin B, Dikstein R. Slobodin B, et al. EMBO Rep. 2020 Sep 3;21(9):e50799. doi: 10.15252/embr.202050799. Epub 2020 Aug 16. EMBO Rep. 2020. PMID: 32803873 Free PMC article. Review.

• Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end.

  Borman AM, Michel YM, Kean KM. Borman AM, et al. Nucleic Acids Res. 2000 Nov 1;28(21):4068-75. doi: 10.1093/nar/28.21.4068. Nucleic Acids Res. 2000. PMID: 11058101 Free PMC article.

• Contribution of 5'- and 3'-untranslated regions of plastid mRNAs to the expression of Chlamydomonas reinhardtii chloroplast genes.

  Barnes D, Franklin S, Schultz J, Henry R, Brown E, Coragliotti A, Mayfield SP. Barnes D, et al. Mol Genet Genomics. 2005 Dec;274(6):625-36. doi: 10.1007/s00438-005-0055-y. Epub 2005 Oct 18. Mol Genet Genomics. 2005. PMID: 16231149

• Poliovirus 5'-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis.

  Lyons T, Murray KE, Roberts AW, Barton DJ. Lyons T, et al. J Virol. 2001 Nov;75(22):10696-708. doi: 10.1128/JVI.75.22.10696-10708.2001. J Virol. 2001. PMID: 11602711 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal