The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil - PubMed

Clinical Trial

The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil

C Crawley et al. Br J Cancer. 1998 Aug.

Free PMC article

Abstract

The purpose of this study was to review the efficacy of a protracted venous infusion of 5-fluorouracil (PVI 5-FU)-based chemotherapy in advanced small bowel adenocarcinoma. Data on all patients with small bowel malignancy who were seen at a single institution over a 5-year period were retrieved from the gastrointestinal unit and hospital databases, and these cases were reviewed. Eight patients with advanced small bowel adenocarcinoma received PVI 5FU-based chemotherapy. The overall response rate in assessable patients was 37.5% (3/8). The median overall survival was 13 months (range 1-28), and progression-free survival was 7.8 months (range 0-15). Overall, the treatment was well tolerated and symptomatic benefit was seen. In conclusion, PVI 5-FU has activity in this disease. This should be assessed either as a single agent or as part of a combination regimen such as epirubicin/cisplatin/PVI FU (ECF) in a multicentre randomized study.

Similar articles

• Combination chemotherapy in advanced small bowel adenocarcinoma.

  Locher C, Malka D, Boige V, Lebray P, Elias D, Lasser P, Ducreux M. Locher C, et al. Oncology. 2005;69(4):290-4. doi: 10.1159/000089678. Epub 2005 Nov 9. Oncology. 2005. PMID: 16282708

• Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer.

  Ross P, Nicolson M, Cunningham D, Valle J, Seymour M, Harper P, Price T, Anderson H, Iveson T, Hickish T, Lofts F, Norman A. Ross P, et al. J Clin Oncol. 2002 Apr 15;20(8):1996-2004. doi: 10.1200/JCO.2002.08.105. J Clin Oncol. 2002. PMID: 11956258 Clinical Trial.

• First-line protracted venous infusion fluorouracil with CisDDP or carboplatin in advanced colorectal cancer.

  Garcia-Giralt E, Beuzeboc P, Deffontaines D, Diéras V, Dorval T, Jouve M, Palangie T, Scholl S, Pouillart P. Garcia-Giralt E, et al. J Infus Chemother. 1996 Summer;6(3):149-51. J Infus Chemother. 1996. PMID: 9229328 Clinical Trial.

• Management of small bowel adenocarcinoma.

  Kummar S, Ciesielski TE, Fogarasi MC. Kummar S, et al. Oncology (Williston Park). 2002 Oct;16(10):1364-9; discussion 1370, 1372-3. Oncology (Williston Park). 2002. PMID: 12435206 Review.

Cited by

• Blood loss anemia due to adenocarcinoma of the jejunum: case report and review of the literature.

  Figueira-Coelho J, Lourenço S, Costa M, Mendonça P, Murinello A, Neta J. Figueira-Coelho J, et al. Cases J. 2009 Feb 18;2:6237. doi: 10.4076/1757-1626-2-6237. Cases J. 2009. PMID: 19918564 Free PMC article.

• Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.

  Eigenbrod T, Kullmann F, Klebl F. Eigenbrod T, et al. Int J Gastrointest Cancer. 2006;37(2-3):94-7. doi: 10.1007/s12029-007-0005-5. Int J Gastrointest Cancer. 2006. PMID: 17827529

• Management of Advanced Small Bowel Cancer.

  Puccini A, Battaglin F, Lenz HJ. Puccini A, et al. Curr Treat Options Oncol. 2018 Nov 5;19(12):69. doi: 10.1007/s11864-018-0592-3. Curr Treat Options Oncol. 2018. PMID: 30397729 Free PMC article. Review.

• Small bowel adenocarcinoma.

  Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ. Zouhairi ME, et al. Curr Treat Options Oncol. 2008 Dec;9(4-6):388-99. doi: 10.1007/s11864-009-0098-0. Epub 2009 Apr 14. Curr Treat Options Oncol. 2008. PMID: 19365735 Review.

• The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study.

  Sakae H, Kanzaki H, Nasu J, Akimoto Y, Matsueda K, Yoshioka M, Nakagawa M, Hori S, Inoue M, Inaba T, Imagawa A, Takatani M, Takenaka R, Suzuki S, Fujiwara T, Okada H. Sakae H, et al. Br J Cancer. 2017 Nov 21;117(11):1607-1613. doi: 10.1038/bjc.2017.338. Epub 2017 Oct 5. Br J Cancer. 2017. PMID: 28982111 Free PMC article.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Nature Publishing Group
  • PubMed Central