What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes - PubMed
- ️Thu Jan 01 1998
What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
J Zhang et al. JAMA. 1998.
Abstract
Logistic regression is used frequently in cohort studies and clinical trials. When the incidence of an outcome of interest is common in the study population (>10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio. The more frequent the outcome, the more the odds ratio overestimates the risk ratio when it is more than 1 or underestimates it when it is less than 1. We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk.
Comment in
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Correcting the odds ratio in cohort studies of common outcomes.
McNutt LA, Hafner JP, Xue X. McNutt LA, et al. JAMA. 1999 Aug 11;282(6):529. doi: 10.1001/jama.282.6.529. JAMA. 1999. PMID: 10450713 No abstract available.
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