Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling - PubMed

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

K Zhao et al. Cell. 1998.

Free article

Abstract

Lymphocyte activation is accompanied by visible changes in chromatin structure. We find that antigen receptor signaling induces the rapid association of the BAF complex with chromatin. PIP2, which is regulated by activation stimuli, is sufficient in vitro to target the BAF complex to chromatin, but it has no effect on related chromatin remodeling complexes containing SNF2L or hISWI. Purification and peptide sequencing of the subunits of the complex revealed beta-actin as well as a novel actin-related protein, BAF53. beta-actin and BAF53 are required for maximal ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix. This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation.

Similar articles

• Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.

  Rando OJ, Zhao K, Janmey P, Crabtree GR. Rando OJ, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9. doi: 10.1073/pnas.032662899. Proc Natl Acad Sci U S A. 2002. PMID: 11880634 Free PMC article.

• Functional selectivity of recombinant mammalian SWI/SNF subunits.

  Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM. Kadam S, et al. Genes Dev. 2000 Oct 1;14(19):2441-51. doi: 10.1101/gad.828000. Genes Dev. 2000. PMID: 11018012 Free PMC article.

• Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex.

  Nishimoto N, Watanabe M, Watanabe S, Sugimoto N, Yugawa T, Ikura T, Koiwai O, Kiyono T, Fujita M. Nishimoto N, et al. J Cell Sci. 2012 Aug 15;125(Pt 16):3870-82. doi: 10.1242/jcs.104349. Epub 2012 May 8. J Cell Sci. 2012. PMID: 22573825

• Nuclear actin and actin-related proteins in chromatin remodeling.

  Olave IA, Reck-Peterson SL, Crabtree GR. Olave IA, et al. Annu Rev Biochem. 2002;71:755-81. doi: 10.1146/annurev.biochem.71.110601.135507. Epub 2001 Nov 9. Annu Rev Biochem. 2002. PMID: 12045110 Review.

• BAFfling pathologies: Alterations of BAF complexes in cancer.

  Arnaud O, Le Loarer F, Tirode F. Arnaud O, et al. Cancer Lett. 2018 Apr 10;419:266-279. doi: 10.1016/j.canlet.2018.01.046. Epub 2018 Jan 31. Cancer Lett. 2018. PMID: 29374542 Review.

Cited by

• The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

  Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. Vogel-Ciernia A, et al. Nat Neurosci. 2013 May;16(5):552-61. doi: 10.1038/nn.3359. Epub 2013 Mar 24. Nat Neurosci. 2013. PMID: 23525042 Free PMC article.

• Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex.

  Marcum RD, Reyes AA, He Y. Marcum RD, et al. Biology (Basel). 2020 Jun 30;9(7):146. doi: 10.3390/biology9070146. Biology (Basel). 2020. PMID: 32629987 Free PMC article. Review.

• Nuclear actin and lamins in viral infections.

  Cibulka J, Fraiberk M, Forstova J. Cibulka J, et al. Viruses. 2012 Mar;4(3):325-47. doi: 10.3390/v4030325. Epub 2012 Feb 28. Viruses. 2012. PMID: 22590674 Free PMC article. Review.

• Nuclear localization of actin requires AC102 in Autographa californica multiple nucleopolyhedrovirus-infected cells.

  Gandhi KM, Ohkawa T, Welch MD, Volkman LE. Gandhi KM, et al. J Gen Virol. 2012 Aug;93(Pt 8):1795-1803. doi: 10.1099/vir.0.041848-0. Epub 2012 May 16. J Gen Virol. 2012. PMID: 22592260 Free PMC article.

• A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.

  Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE. Sheu SH, et al. Cell. 2022 Sep 1;185(18):3390-3407.e18. doi: 10.1016/j.cell.2022.07.026. Cell. 2022. PMID: 36055200 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)

• Research Materials

  • Addgene Non-profit plasmid repository

• Miscellaneous

  • NCI CPTAC Assay Portal