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Antigen localization and migration in immunity and tolerance - PubMed

  • ️Thu Jan 01 1998

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Antigen localization and migration in immunity and tolerance

T E Starzl et al. N Engl J Med. 1998.

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Figures

Figure 1
Figure 1. Distribution of Donor Leukocytes (Circles) Three Months after Kidney Transplantation

With the nearly complete disappearance from the allograft of donor leukocytes, the absence of which reduces the organ’s Immunogenicity, the recipient’s leukocytes replace them. The appearance of chimerism is visible in the nonlymphoid organs (skin, heart, and liver are shown), as is the communication between the nonlymphoid compartments and lymphoid compartments (spleen, thymus, lymph nodes, and bone marrow).

Figure 2
Figure 2. Potential Outcomes after Infection with Noncytopathic Microorganisms and Analogies (Expressed as Rejection or Graft-versus-Host Disease) to Organ and Bone Marrow Transplantation

The horizontal axis denotes time. The vertical axis shows the magnitude of the viral load (V, solid line) and the host immune response (IR, dashed line). In Panel D, the IR is absent (straight dashed line) or minimal. GVHD denotes graft-versus-host disease.

Figure 3
Figure 3. Contemporaneous Host-versus-Graft (HVG) and Graft-versus-Host (GVH) Reactions after Transplantation

Failure is defined as the inability to control one or sometimes both of the reactions. Acute reciprocal clonal exhaustion after successful transplantation is subsequently maintained by chimerism-dependent low-grade stimulation of both leukocyte populations, which may wax and wane.

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