Bone stem cells - PubMed

Affiliations

• PMID: 9893258

Review

Bone stem cells

J E Aubin. J Cell Biochem Suppl. 1998.

Abstract

Osteoblasts are the skeletal cells responsible for synthesis, deposition, and mineralization of the extracellular matrix of bone. By mechanisms that are only beginning to be understood, stem and primitive osteoprogenitors and related mesenchymal precursors arise in the embryo and at least some appear to persist in the adult organism, where they contribute to replacement of osteoblasts in bone turnover and in fracture healing. In this paper, the nature of these cells, whether they constitute a stem cell pool or a committed progenitor pool, and aspects of their apparent plasticity are discussed. Current understanding of differential expression of osteoblast-associated genes during osteoprogenitor proliferation and differentiation to mature matrix synthesizing osteoblasts is summarized. Finally, evidence is discussed that supports the hypothesis that the mature osteoblast phenotype is heterogeneous with subpopulations of osteoblasts expressing only subsets of the known osteoblast markers, raising also the possibility of multiple parallel differentiation pathways and perhaps even different progenitor pools.

Similar articles

• Advances in the osteoblast lineage.

  Aubin JE. Aubin JE. Biochem Cell Biol. 1998;76(6):899-910. Biochem Cell Biol. 1998. PMID: 10392704 Review.

• Bone stem cells.

  Aubin JE. Aubin JE. J Cell Biochem. 1998;72 Suppl 30-31(S30-31):73-82. doi: 10.1002/(SICI)1097-4644(1998)72:30/31+<73::AID-JCB11>3.0.CO;2-L. J Cell Biochem. 1998. PMID: 29345825

• Modeling stem cell development by retrospective analysis of gene expression profiles in single progenitor-derived colonies.

  Madras N, Gibbs AL, Zhou Y, Zandstra PW, Aubin JE. Madras N, et al. Stem Cells. 2002;20(3):230-40. doi: 10.1634/stemcells.20-3-230. Stem Cells. 2002. PMID: 12004081

• Fetal bone cells for tissue engineering.

  Montjovent MO, Burri N, Mark S, Federici E, Scaletta C, Zambelli PY, Hohlfeld P, Leyvraz PF, Applegate LL, Pioletti DP. Montjovent MO, et al. Bone. 2004 Dec;35(6):1323-33. doi: 10.1016/j.bone.2004.07.001. Bone. 2004. PMID: 15589213

• Ets transcription factors and targets in osteogenesis.

  Raouf A, Seth A. Raouf A, et al. Oncogene. 2000 Dec 18;19(55):6455-63. doi: 10.1038/sj.onc.1204037. Oncogene. 2000. PMID: 11175361 Review.

Cited by

• Osteocytic FGF23 and Its Kidney Function.

  Agoro R, Ni P, Noonan ML, White KE. Agoro R, et al. Front Endocrinol (Lausanne). 2020 Aug 28;11:592. doi: 10.3389/fendo.2020.00592. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32982979 Free PMC article. Review.

• Different effects of BMP-2 on marrow stromal cells from human and rat bone.

  Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. Osyczka AM, et al. Cells Tissues Organs. 2004;176(1-3):109-19. doi: 10.1159/000075032. Cells Tissues Organs. 2004. PMID: 14745240 Free PMC article.

• Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells.

  Au A, Boehm CA, Mayes AM, Muschler GF, Griffith LG. Au A, et al. Biomaterials. 2007 Apr;28(10):1847-61. doi: 10.1016/j.biomaterials.2006.12.009. Epub 2007 Jan 11. Biomaterials. 2007. PMID: 17222453 Free PMC article.

• DDIT3 overexpression increases odontoblastic potential of human dental pulp cells.

  Wu Y, Sun H, Song F, Fu D, Wang J. Wu Y, et al. Cell Prolif. 2014 Jun;47(3):249-57. doi: 10.1111/cpr.12104. Epub 2014 Apr 16. Cell Prolif. 2014. PMID: 24738922 Free PMC article.

• Mesothelial cell differentiation into osteoblast- and adipocyte-like cells.

  Lansley SM, Searles RG, Hoi A, Thomas C, Moneta H, Herrick SE, Thompson PJ, Newman M, Sterrett GF, Prêle CM, Mutsaers SE. Lansley SM, et al. J Cell Mol Med. 2011 Oct;15(10):2095-105. doi: 10.1111/j.1582-4934.2010.01212.x. J Cell Mol Med. 2011. PMID: 21070599 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Medical

  • MedlinePlus Health Information