Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints - PubMed

Clinical Trial

Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints

M K Parmar et al. Stat Med. 1998.

Erratum in

• Stat Med. 2004 Jun 15;23(11):1817

Abstract

Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival-type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.

Comment in

• Phase III trial of concurrent thoracic radiotherapy with either first- or third-cycle chemotherapy for limited-disease small-cell lung cancer.

  Lueza B, Le Péchoux C, Pignon JP. Lueza B, et al. Ann Oncol. 2014 Sep;25(9):1865-1866. doi: 10.1093/annonc/mdu221. Epub 2014 Jun 11. Ann Oncol. 2014. PMID: 24920790 No abstract available.

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