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eIF4A interacts with eIF4G, and eIF4E interacts with the amino-terminal domain of eIF4G to form the cap-binding complex eIF4F.

Literature References

PubMed ID	Title	Journal	Year
8449919	The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. Yoder-Hill, J, Merrick, WC, Pause, A, Sonenberg, N	J Biol Chem	1993

Participants

Input

Output

eIF4F [cytosol] (Homo sapiens)

Participates

as an event of

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)

Orthologous Events

Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)

Formation of the cap-binding eIF4F complex (Canis familiaris)

Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)

Formation of the cap-binding eIF4F complex (Drosophila melanogaster)

Formation of the cap-binding eIF4F complex (Mus musculus)

Formation of the cap-binding eIF4F complex (Rattus norvegicus)

Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)

Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)