The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children

“…The results of this review, as already outlined, suggest an overall positive association between AD and ASD [30,[35][36][37][38][40][41][42][43][44][45][46][47]. Although this is the general result of the review, some studies are going in the opposite direction [31][32][33][34]39].…”

“…It is possible that calculating the OR without taking into account the severity of AD in children may underestimate the calculated risk of developing ASD. On the other hand, it should be considered that ASD severity and ASD symptoms also seem to be correlated with the prevalence of AD, as suggested in the studies by Mostafa et al [35][36][37], who found a positive correlation between ASD severity and prevalence of AD, and in the study by Shibata et al [42], who showed a positive association between AD and some of the core behavioral symptoms of ASD. Furthermore, some evidence shows that comorbidity with ADHD has an additive effect on the risk of atopic diseases in children with ASD [45].…”