Qufeng Tongluo Prescription (祛风通络方) inhibits mesangial cell proliferation and promotes apoptosis through regulating cell cycle progression
“…In addition to improving the glomerular filtration function, QTR could also inhibit the accumulation of ECM by reducing the expressions of Col IV, fibronectin, and laminin in kidney tissues and downregulate the expression of renal fibrosis-related proteins α-SMA and vimentin, thus playing an antifibrosis role ( Wu et al, 2008 ; Ma et al, 2019 ). The results in vitro indicated that the inhibition of QTR on the proliferation of mesangial cells was related to the regulation of the cell cycle process and the inhibition of TGF expression ( Sun et al, 2008 ; Wu et al, 2013 ). The regulation of cell cycle progression is reflected in the reduction of the protein and mRNA expression levels of cylinD1, cyclin-dependent kinase 2 (CDK2), and p21 and the increase of p27.…”
Section: Tcm For Treating Ckdmentioning
“…In addition to improving the glomerular filtration function, QTR could also inhibit the accumulation of ECM by reducing the expressions of Col IV, fibronectin, and laminin in kidney tissues and downregulate the expression of renal fibrosis-related proteins α-SMA and vimentin, thus playing an antifibrosis role ( Wu et al, 2008 ; Ma et al, 2019 ). The results in vitro indicated that the inhibition of QTR on the proliferation of mesangial cells was related to the regulation of the cell cycle process and the inhibition of TGF expression ( Sun et al, 2008 ; Wu et al, 2013 ). The regulation of cell cycle progression is reflected in the reduction of the protein and mRNA expression levels of cylinD1, cyclin-dependent kinase 2 (CDK2), and p21 and the increase of p27.…”
Section: Tcm For Treating Ckdmentioning
“…The Qufeng Tongluo Prescription originated from "Qian Jia Miao Fang." This medicine dispels the wind, reduces phlegm, relaxes collaterals, and nourishes the blood and liver (Wu et al, 2013). Qufeng Tongluo significantly increases ChAT expression in a VD rat model, which improves cholinergic system function and memory in the VD rat model (Park et al, 2009).…”
Section: The Cholinergic System In Vdmentioning
“…Studies have shown that Shengjiang powder improves cognitive dysfunction in VD rats by increasing the Ach levels in the hippocampus and reducing AchE activity ( Ge et al, 2015 ). The Qufeng Tongluo Prescription originated from “Qian Jia Miao Fang.” This medicine dispels the wind, reduces phlegm, relaxes collaterals, and nourishes the blood and liver ( Wu et al, 2013 ). Qufeng Tongluo significantly increases ChAT expression in a VD rat model, which improves cholinergic system function and memory in the VD rat model ( Park et al, 2009 ).…”
Section: The Cholinergic System In Vdmentioning