Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin

“…Conversely, exogenous adiponectin alleviates chronic inflammation, glucose intolerance, and insulin resistance in obese and diabetic rodents (24)(25)(26). Adiponectin exerts its effects through two adiponectin receptors, AdipoR1 and AdipoR2 (24,27). Adiponectin also activates liver kinase B1-AMPK signaling pathways, promoting insulin sensitivity (23,27).…”