Lineage stability and phenotypic plasticity of Foxp3<sup>+</sup> regulatory T cells
“…We could thus conclude that biTregs do not derive from Th17 cells or cTregs. Our findings therefore support the Foxp3 lineage heterogeneity model recently proposed by Hori 35 rather than Foxp3/Th17 lineage plasticity. However, it has also been postulated that Foxp3 might be transiently induced in non-Treg CD4 + T cells during their activation.…”
Section: Foxp3supporting
“…There is concern that, if Tregs can change to effector lineage, their use as therapy may be unreliable, if not dangerous (144)(145)(146)(147). At present, the consensus is that nTregs/tTregs that have demethylation of TSDR are stable, and their progeny remain Tregs (144,145).…”
Section: Do Spies Become Soldiers?mentioning
“…At present, the consensus is that nTregs/tTregs that have demethylation of TSDR are stable, and their progeny remain Tregs (144,145). nTregs have demethylation of regions of other genes essential to their function, including CTLA4 and GITR (148).…”
Section: Do Spies Become Soldiers?mentioning
“…Tregs are characterized by their expression of the X-linked forkhead transcription factor FOXP3, which plays essential roles for the establishment and maintenance of Treg identity and suppressive function (12)(13)(14)(15). The lineage stability and phenotypic plasticity of Tregs ensure the robustness of tolerance and tissue homeostasis (16). Recent studies have suggested, however, that Tregs may retain lineage plasticity, the ability to switch their cell fate to various T effector (Teff) cell types, under certain circumstances, such as inflammation (16).…”
Section: Introductionmentioning
“…The lineage stability and phenotypic plasticity of Tregs ensure the robustness of tolerance and tissue homeostasis (16). Recent studies have suggested, however, that Tregs may retain lineage plasticity, the ability to switch their cell fate to various T effector (Teff) cell types, under certain circumstances, such as inflammation (16).…”
Section: Introductionmentioning