Bradykinin-Mediated Diseases

“…1,2,5,6 Kallikrein cleaves HK to release the nanopeptide bradykinin, which contributes to inflammation, vasodilatation, and vascular permeability through interactions with specific cellular receptors. 3,4,6,7 Excessive bradykinin formation due to accelerated activation or dysregulation of the KKS contributes to a range of pathologies including angioedema (rapid soft tissue swelling). 4,7,8 In hereditary angioedema (HAE), which affects ;1 in 50 000 individuals, 9,10 patients experience episodic swelling of the face, airway, limbs, or gastrointestinal tract.…”