Bone Mineral Density Changes Among Women Initiating Proton Pump Inhibitors or H2 Receptor Antagonists: A SWAN Cohort Study
“…This latter study also reported that in the USA the proportion of patients who received an osteoporosis medication was lower after the index hip fracture than before [15]. Moreover, several studies carried out in both the USA and Europe reported that over the past decade there was a significant decrease in the rate of osteoporosis medication after hip fracture, which may be related to concerns over potential side effects of bisphosphonates [15,18]. The reasons for the gap between national and international evidence-based treatment guidelines [10,19] and treatment rates remain unclear and have been debated in several studies [8,20].…”
Section: Discussionmentioning
“…This latter study also reported that in the USA the proportion of patients who received an osteoporosis medication was lower after the index hip fracture than before [15]. Moreover, several studies carried out in both the USA and Europe reported that over the past decade there was a significant decrease in the rate of osteoporosis medication after hip fracture, which may be related to concerns over potential side effects of bisphosphonates [15,18]. The reasons for the gap between national and international evidence-based treatment guidelines [10,19] and treatment rates remain unclear and have been debated in several studies [8,20].…”
Section: Discussionmentioning
“…[7] confirmed an increased fracture risk after the use of PPIs . In contrast, only one [13] of five prospective studies [11][12][13][14][15] found a significant negative association between PPI use and BMD at the hip, but not at other sites.…”
Section: Discussionmentioning
“…Except for the prospective cross-sectional study by Targownik et al [11], the studies investigating PPI use and BMD were prospective cohort studies (Canadian Multicentre Osteoporosis Study (CaMos) [12], Women's Health Initiative (WHI) Observational Study and Clinical Trials [13], Osteoporotic Fractures in Men Study (MrOS) and Study of Osteoporotic Fractures (SOF) [14], and Study of Women's Health Across the Nation (SWAN) [15]). …”
Section: Discussionmentioning
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“…Finally, a recent survey of the Study of Women's Health Across the Nation (SWAN) found no change in BMD at the lumbar spine, femoral neck, or total hip between users of PPIs, H2 receptor antagonists, or non-users [19].…”
Section: Effect Of Ppis On Bone Mineral Densitymentioning