Human Ghrelin Mitigates Intestinal Injury and Mortality after Whole Body Irradiation in Rats

“…It acts through specific receptors located, among other structures, in the central nervous system and many peripheral organs. Apart from its regulatory function, which is necessary for control of energy balance by stimulating appetite, regulation of gastrointestinal system functions, and adipose tissue storage, ghrelin is also responsible for inhibiting the inflammatory response by reducing the production of proinflammatory cytokine and intensifying the production of anti‐inflammatory cytokine . It was also demonstrated in animal models that administration of ghrelin significantly reduces the postirradiation inflammatory reaction and the associated infections .…”