Release of chemical transmitters from cell bodies and dendrites of nerve cells

“…Further, to support this assumption, here we show the simultaneous [ 3 H]Glu efflux in response to an identical optogenetic stimulation ( Figure 4G ). Because light stimulation-evoked 5-HT efflux was sensitive to TTX, the released 5-HT and Glu are probably originated from distinct nerve terminal populations and 5-HT might also be derived from dendrites and cell bodies ( De-Miguel and Nicholls, 2015 ). It is well known that 5-HT is secreted from the somata and dendrites of neurons in the raphe nuclei in response to the activation of NMDA receptors in a [Ca 2+ ] o -dependent way ( de Kock et al, 2006 ; Harsing, 2006 ), and the majority of 5-HT is released in a non-synaptic manner ( Harsing, 2006 ; Vizi et al, 2010 ).…”