Allosteric proteins as logarithmic sensors

“…Like cooperativity, allostery also modulates sensor properties. Typically, the binding of an allosteric effector to a site outside the primary ligand's binding site modulates the input-output response curve (Olsman and Goentoro, 2016) (the activation function, by our terminology). An allosteric sensor can, therefore, exist in more than one active state, e.g., k, states, each with a different activation function, h i ðxÞ (STAR Methods and Figure S1A).…”