Prospective study of Type 2 diabetes mellitus, anti-diabetic drugs and risk of prostate cancer
“…A meta‐analysis of 45 studies reported 14% risk reduction of prostate cancer in diabetic patients . Furthermore, two other studies provided evidence for an inverse association between diabetes and prostate cancer . A few previous studies have reported positive or no associations, likely due to small sample size or short follow‐up time .…”
Section: Discussionmentioning
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“…A meta‐analysis of 45 studies reported 14% risk reduction of prostate cancer in diabetic patients . Furthermore, two other studies provided evidence for an inverse association between diabetes and prostate cancer . A few previous studies have reported positive or no associations, likely due to small sample size or short follow‐up time .…”
Section: Discussionmentioning
“…42 Furthermore, two other studies provided evidence for an inverse association between diabetes and prostate cancer. 20,43 A few previous studies have reported positive or no associations, likely due to small sample size or short follow-up time. 24,44 Men with diabetes have lower circulating testosterone concentrations, 45 and decreased testosterone may reduce the risk of prostate cancer.…”
Section: Discussionmentioning
“…In a study based on meta-analysis, pre-existing type 2 diabetes was reported to be associated with all-cause mortality [5]. More recent data indicate that diabetes did not adversely impact survival in patients with prostate cancer [6] [7] [8].…”
Section: Introduction or Backgroundmentioning
“…43,44 Diabetes is also a prognostic factor that influences clinical outcomes in cancer. [45][46][47][48] However, a study by Häggström et al 49 provided no support to the hypothesis that metformin protects against prostate cancer.…”
Section: Potential Use In Oncologymentioning