Ion channel mechanisms underlying frequency-firing patterns of the avian nucleus magnocellularis: A computational model
2017
Abstract: We have previously shown that late-developing avian nucleus magnocellularis (NM) neurons (embryonic [E] days 19–21) fire action potentials (APs) that resembles a band-pass filter in response to sinusoidal current injections of varying frequencies. NM neurons located in the mid- to high-frequency regions of the nucleus fire preferentially at 75 Hz, but only fire a single onset AP to frequency inputs greater than 200 Hz. Surprisingly, NM neurons do not fire APs to sinusoidal inputs less than 20 Hz regardless of … Show more
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“…This model is designed based on our previous study (Lu et al . ), in combination with the I NaR model from Khaliq et al . ().…”
Section: Resultsmentioning
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“…This model is designed based on our previous study (Lu et al . ), in combination with the I NaR model from Khaliq et al . ().…”
Section: Resultsmentioning
“…Based on NM models previously described in detail elsewhere (Howard & Rubel, 2010;Lu et al 2017), a singlecompartment computational model was constructed using NEURON 7.1 (Table 1) (Hines & Carnevale, 1997). This model contains currents mediated by low and high voltage-activated potassium channels (K LVA and K HVA , respectively), Na V and passive leak channels.…”
Section: Computational Modellingmentioning
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“…Ion channels, in particular low-voltage activated potassium channels (K LVA ) guard neuronal excitability and shape individual neurons’ frequency-firing patterns. The article by Lu et al, 1 published in the current issue demonstrates how differential expression of K LVA channels generates unique filtering properties that tune neurons to their stimulus-specific inputs.…”
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