Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR)

“…To account for potential confounding by tumor MSI status, we further evaluated these associations jointly by tumorinfiltrated T cells and MSI status. Lastly, we assessed the associations stratified by tumor CASR status because we speculated that CASR may partially mediate the potential effect of calcium on colorectal cancer immunoprevention (9). All analyses were performed using the SAS software (SAS Institute, Version 9.2).…”

“…Details on assessments of calcium intake, as well as other dietary factors were described previously (2,9,21). In brief, we used validated (22,23) semiquantitative food frequency questionnaires (FFQ) to collect dietary information at baseline and every 4 year thereafter.…”