NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis

“…Our results are consistent with their findings suggesting increased NAMPT levels as the worst prognosticator in GBM samples. NAMPT has been suggested to act as a dedifferentiation inducer gene controlling energy core axis for glioma cancer stem like cells maintenance . Liu et al reported that elevated levels of NAMPT in the serum of small cell lung cancer (SCLC) patients were associated with brain metastasis and CCL2 was involved in transendothelial migration of tumor cells across the BBB.…”

“…Lucena‐Cacace et al suggested that high expression of NAMPT and SERPINE1 correlated with IDH1 wild type GBM tumors leading to the worst prognosis. They also proposed that NAMPT overexpression in glioma cell lines increases the tumorogenic properties . IDH wild type LGG vessels are molecularly distinct from the IDH1 mutated, therefore indicative of vascular remodeling and angiogenesis .…”